Protein Summary
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
- ENST00000303498
- ENSP00000306477
- ENSG00000169814
- ENST00000383778
- ENSP00000373288
- ENST00000427382
- ENSP00000397113
- ENST00000437172
- ENSP00000400995
- ENST00000449107
- ENSP00000388212
- ENST00000643237
- ENSP00000495254
- ENST00000646371
- ENSP00000495866
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.9 | ||
histone modification site profile | 0.9 | ||
co-expressed gene | 0.79 | ||
transcription factor binding site profile | 0.77 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.28 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 202 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.28 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 202 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0