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Tchem
GRK6
G protein-coupled receptor kinase 6

Protein Summary
Description
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355472
  • ENSP00000347655
  • ENSG00000198055
  • ENST00000355958
  • ENSP00000348230
  • ENST00000528793
  • ENSP00000433511

Symbol
  • GPRK6
  • GPRK6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor perturbation
0.97
molecular function
0.94
transcription factor
0.87
transcription factor binding site profile
0.81


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.76   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.76   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
balanol
Rendered image for balanol
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
8
11
15.2
99.3
creatinine measurement
5
6
7
97
partial thromboplastin time
2
2
2
96.1
hematocrit
5
5
5
96.1
hemoglobin measurement
4
4
4
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
11
15.2
99.3
creatinine measurement
7
97
partial thromboplastin time
2
96.1
hematocrit
5
96.1
hemoglobin measurement
4
94.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor kinase 6
700000
Mouse
MGI:1347078
26385
Rat
RGD:61986
59076
Dog
G protein-coupled receptor kinase 6
VGNC:41506
100684653
Horse
G protein-coupled receptor kinase 6
VGNC:18597
100068570
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor kinase 6
Mouse
Rat
Dog
G protein-coupled receptor kinase 6
Horse
G protein-coupled receptor kinase 6
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43250-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (81)
1 – 10 of 81
GRK5
Tchem
Family:  Kinase
Novelty:  0.01108012
p_int:  1
Score:  0.939
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.999983441
p_ni:  0.000016559
Data Source:  BioPlex
RUBCNL
Tbio
Novelty:  0.20019585
p_int:  0.999051641
p_ni:  0.000939456
p_wrong:  0.000008903
Data Source:  BioPlex
NOLC1
Tbio
Novelty:  0.01922261
p_int:  0.998700025
p_ni:  0.001299975
Score:  0.173
Data Source:  BioPlex,STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.998023906
p_ni:  0.001946184
p_wrong:  0.00002991
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.995085781
p_ni:  0.004914196
p_wrong:  2.3e-8
Data Source:  BioPlex
ENDOG
Tbio
Family:  Enzyme
Novelty:  0.00404275
p_int:  0.994887467
p_ni:  0.005112533
Score:  0.204
Data Source:  BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.994117215
p_ni:  0.005882717
p_wrong:  6.8e-8
Data Source:  BioPlex
CD83
Tbio
Novelty:  0.00138653
p_int:  0.951964546
p_ni:  0.047742224
p_wrong:  0.000293229
Data Source:  BioPlex
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.933026631
p_ni:  0.066717261
p_wrong:  0.000256109
Score:  0.216
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  46.76

PubMed score by year
PubTator Score  64.65

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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