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Tbio
MSH2
DNA mismatch repair protein Msh2

Protein Summary
Description
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containg DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233146
  • ENSP00000233146
  • ENSG00000095002
  • ENST00000543555
  • ENSP00000442697

Symbol
  • FCC1
  • COCA1
  • HNPCC
  • LCFS2
  • hMSH2
  • HNPCC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
interacting protein
1
molecular function
1
biological process
0.99
hub protein
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1841.27   (req: < 5)
Gene RIFs: 469   (req: <= 3)
Antibodies: 613   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1841.27   (req: >= 5)
Gene RIFs: 469   (req: > 3)
Antibodies: 613   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
1
1
0
40.3
4.2
appendicular lean mass
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
0
40.3
4.2
appendicular lean mass
1
1.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mutS homolog 2
718017
Mouse
MGI:101816
17685
Rat
RGD:620786
81709
Dog
mutS homolog 2
VGNC:43438
494002
Horse
mutS homolog 2
VGNC:20385
100068146
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mutS homolog 2
Mouse
Rat
Dog
mutS homolog 2
Horse
mutS homolog 2
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43246-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Defective Mismatch Repair Associated With MSH2
Reactome
Defective Mismatch Repair Associated With MSH3
Reactome
Defective Mismatch Repair Associated With MSH6
Reactome
Disease
Name
Explore in Pharos
Explore in Source
DNA Repair
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH3
Defective Mismatch Repair Associated With MSH6
Disease
Gene Ontology Terms (44)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (376)
1 – 10 of 376
MLH1
Tbio
Novelty:  0.00034212
Score:  0.999
Data Source:  Reactome,STRINGDB
PMS2
Tbio
Family:  Enzyme
Novelty:  0.00139084
Score:  0.999
Data Source:  Reactome,STRINGDB
MSH3
Tbio
Novelty:  0.0036266
Score:  0.999
Data Source:  Reactome,STRINGDB
EXO1
Tbio
Family:  Enzyme
Novelty:  0.00130104
Score:  0.999
Data Source:  Reactome,STRINGDB
MSH6
Tbio
Family:  Epigenetic
Novelty:  0.00097439
Score:  0.999
Data Source:  Reactome,STRINGDB
ERCC1
Tbio
Novelty:  0.00079472
Score:  0.997
Data Source:  STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.997
Data Source:  Reactome,STRINGDB
POLD1
Tclin
Family:  Enzyme
Novelty:  0.00508209
Score:  0.996
Data Source:  STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.993
Data Source:  STRINGDB
PMS1
Tbio
Family:  TF
Novelty:  0.00444827
Score:  0.991
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1841.27

PubMed score by year
PubTator Score  1686.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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