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Tbio
MATR3
Matrin-3

Protein Summary
Description
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233). This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394805
  • ENSP00000378284
  • ENSG00000015479
  • ENST00000503811
  • ENSP00000423587
  • ENST00000618441
  • ENSP00000482895

Symbol
  • KIAA0723
  • MPD2
  • ALS21
  • VCPDM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
transcription factor binding site profile
0.92
microRNA
0.89
ligand (protein) perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.97   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.97   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (212)
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.857199463
p_ni:  0.142800537
Score:  0.273
Data Source:  BioPlex,STRINGDB
CDK5RAP1
Tbio
Novelty:  0.0347805
p_int:  0.766531876
p_ni:  0.233468124
Score:  0.297
Data Source:  BioPlex,STRINGDB
SFPQ
Tbio
Novelty:  0.01207637
Score:  0.995
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.985
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.985
Data Source:  STRINGDB
NONO
Tbio
Novelty:  0.00501502
Score:  0.981
Data Source:  STRINGDB
HNRNPA2B1
Tbio
Novelty:  0.00404935
Score:  0.979
Data Source:  STRINGDB
HNRNPK
Tbio
Novelty:  0.00354731
Score:  0.979
Data Source:  STRINGDB
HNRNPM
Tbio
Novelty:  0.0125566
Score:  0.977
Data Source:  STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.974
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
1
1
86.9
viral load
1
1
1
66.8
electrocardiography
1
1
4
62.1
reticulocyte count
1
1
1
49.5
reticulocyte measurement
2
1
2
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
86.9
viral load
1
66.8
electrocardiography
4
62.1
reticulocyte count
1
49.5
reticulocyte measurement
2
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrin 3
100568449
Macaque
matrin 3
100568450
Mouse
MGI:1298379
17184
Rat
RGD:3052
29150
Dog
matrin 3
474700
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrin 3
Macaque
matrin 3
Mouse
Rat
Dog
matrin 3
Publication Statistics
PubMed Score 99.97
PubMed score by year
PubTator Score 59.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title