Protein Summary
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]
- ENST00000433477
- ENSP00000414904
- ENSG00000256043
- ENST00000573499
- ENSP00000460395
- ENSG00000263238
- CTSO1
- CTSO1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.91 | ||
histone modification site profile | 0.86 | ||
microRNA | 0.59 | ||
protein domain | 0.58 | ||
cell type or tissue | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.9 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 125 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.9 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 125 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (77)
KNG1
Novelty: 0.00007684
p_int: 0.999990261
p_ni: 0.000009734
p_wrong: 5e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
LYPLA1
Family: Enzyme
Novelty: 0.01217068
p_int: 0.999749531
p_ni: 0.000184712
p_wrong: 0.000065758
Score: 0.517
Data Source: BioPlex,STRINGDB
GRN
Novelty: 0.00096395
p_int: 0.999164815
p_ni: 0.000835185
Score: 0.446
Data Source: BioPlex,STRINGDB
CSTA
Novelty: 0.00453121
p_int: 0.998751014
p_ni: 0.000004231
p_wrong: 0.001244755
Score: 0.302
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (3)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Immune System | ||||
Reactome | MHC class II antigen presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Immune System | ||||
MHC class II antigen presentation | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (1)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
blood metabolite measurement | 1 | 1 | 1 | 51.4 | ||||||
blood metabolite measurement | 1 | 1 | 1 | 51.4 | ||||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
blood metabolite measurement | 1 | 51.4 | |||||
blood metabolite measurement | 1 | 51.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cathepsin O | VGNC:10852 | 461567 | |||||
Macaque | cathepsin O | 699868 | ||||||
Mouse | MGI:2139628 | 229445 | ||||||
Dog | cathepsin O | VGNC:54198 | 482665 | |||||
Horse | cathepsin O | VGNC:16954 | 100069500 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cathepsin O | |||||
Macaque | cathepsin O | |||||
Mouse | ||||||
Dog | cathepsin O | |||||
Horse | cathepsin O | |||||
Publication Statistics
PubMed Score 9.90
PubMed score by year
PubTator Score 8.83
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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