Tbio CTSO Cathepsin O

Protein Summary

Description

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43234

Gene Name

• CTSO

Ensembl ID

• ENST00000433477
• ENSP00000414904
• ENSG00000256043
• ENST00000573499
• ENSP00000460395
• ENSG00000263238

Symbol

• CTSO1
• CTSO1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
histone modification site profile	0.86
microRNA	0.59
protein domain	0.58
cell type or tissue	0.5

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Cathepsin O

Protein / ... / Protease Inhibitor / Cathepsin O

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Cathepsin O

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

KNG1

Tbio

Novelty:  0.00007684

p_int:  0.999990261

p_ni:  0.000009734

p_wrong:  5e-9

Score:  0.206

Data Source:  BioPlex,STRINGDB

LYPLA1

Tchem

Family:  Enzyme

Novelty:  0.01217068

p_int:  0.999749531

p_ni:  0.000184712

p_wrong:  0.000065758

Score:  0.517

Data Source:  BioPlex,STRINGDB

GRN

Tbio

Novelty:  0.00096395

p_int:  0.999164815

p_ni:  0.000835185

Score:  0.446

Data Source:  BioPlex,STRINGDB

CSTA

Tbio

Novelty:  0.00453121

p_int:  0.998751014

p_ni:  0.000004231

p_wrong:  0.001244755

Score:  0.302

Data Source:  BioPlex,STRINGDB

CD74

Tchem

Novelty:  0.00281228

Score:  0.922

Data Source:  STRINGDB

HLA-DPA1

Tbio

Novelty:  0.01080446

Score:  0.909

Data Source:  STRINGDB

P04229

Tbio

Novelty:  0.00240724

Score:  0.908

Data Source:  STRINGDB

Q95IE3

Tbio

Novelty:  0.00240724

Score:  0.908

Data Source:  STRINGDB

HLA-DRA

Tbio

Novelty:  0.0060214

Score:  0.908

Data Source:  STRINGDB

P13761

Tbio

Novelty:  0.00240724

Score:  0.908

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (3)

KEGG (2)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	MHC class II antigen presentation	120 targets	R-HSA-2132295

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Immune System	2246 targets	R-HSA-168256
MHC class II antigen presentation	120 targets	R-HSA-2132295

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Components (2)

Processes (2)

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GO Term	Evidence	Assigned by
cysteine-type endopeptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	ENSG00000256043	1	1	1		51.4
blood metabolite measurement	EFO_0005664	ENSG00000263238	1	1	1		51.4

Items per page:

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1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	1		51.4
blood metabolite measurement	EFO_0005664	1		51.4

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UniProt Keyword Find Similar Targets

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Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Protease
Reference proteome
Signal
Thiol protease
Zymogen

GWAS Trait Find Similar Targets

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blood metabolite measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
integument phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cathepsin O	VGNC:10852	461567
Macaque	cathepsin O		699868
Mouse	cathepsin O	MGI:2139628	229445
Dog	cathepsin O	VGNC:54198	482665
Horse	cathepsin O	VGNC:16954	100069500

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cathepsin O
Macaque	cathepsin O
Mouse	cathepsin O
Dog	cathepsin O
Horse	cathepsin O

Publication Statistics

PubMed Score 9.90

PubMed score by year

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PubTator Score 8.83

PubTator score by year

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Related Publications

Text Mined References (12)

GeneRif Annotations (3)

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PMID	Year	Title