Tbio CTSO Cathepsin O

Protein Summary

Description

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43234

Gene Name

• CTSO

Ensembl ID

• ENST00000433477
• ENSP00000414904
• ENSG00000256043
• ENST00000573499
• ENSP00000460395
• ENSG00000263238

Symbol

• CTSO1
• CTSO1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
histone modification site profile	0.86
microRNA	0.59
protein domain	0.58
cell type or tissue	0.5

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Cathepsin O

Protein / ... / Protease Inhibitor / Cathepsin O

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Cathepsin O

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.3   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.3   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0