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Tclin
GLP1R
Glucagon-like peptide 1 receptor

Protein Summary
Description
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373256
  • ENSP00000362353
  • ENSG00000112164

Symbol
  • GLP-1
  • GLP-1R
  • GLP-1-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
protein domain
0.85
disease perturbation
0.79
virus perturbation
0.64
small molecule perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1525.22   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 498   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1525.22   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 498   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 214
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
3
1.1
97.8
fasting blood glucose measurement
1
1
1
62.5
glucose measurement
1
1
1
22.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
97.8
fasting blood glucose measurement
1
62.5
glucose measurement
1
22.6
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (190)
1 – 10 of 190
GCG
Tchem
Novelty: 0.00004879
Score: 0.997
Data Source: Reactome,STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.984
Data Source: STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.983
Data Source: STRINGDB
GIP
Tchem
Novelty: 0.0007219
Score: 0.982
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.957
Data Source: STRINGDB
IAPP
Tbio
Novelty: 0.0005195
Score: 0.956
Data Source: STRINGDB
VIP
Tbio
Novelty: 0.00024946
Score: 0.954
Data Source: STRINGDB
SCT
Tbio
Novelty: 0.00070278
Score: 0.954
Data Source: STRINGDB
ADCYAP1
Tbio
Family: Enzyme
Novelty: 0.00080219
Score: 0.951
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  1525.22

PubMed score by year
PubTator Score  2728.41

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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