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Tclin
CA7
Carbonic anhydrase 7

Protein Summary
Description
Reversible hydration of carbon dioxide. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the brain and contributes to bicarbonate driven GABAergic neuron excitation. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338437
  • ENSP00000345659
  • ENSG00000168748
  • ENST00000394069
  • ENSP00000377632

Symbol
  • CAVII
  • CA-VII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
transcription factor
0.68
PubMedID
0.61
protein domain
0.58
drug
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.47   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.47   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 471
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 7
VGNC:9074
740899
Mouse
MGI:103100
12354
Rat
RGD:1306842
291819
Dog
carbonic anhydrase 7
VGNC:38615
489772
Horse
carbonic anhydrase 7
VGNC:51145
100065583
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 7
Mouse
Rat
Dog
carbonic anhydrase 7
Horse
carbonic anhydrase 7
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43166-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (29)
1 – 10 of 29
CYP24A1
Tchem
Family: Enzyme
Novelty: 0.00107155
Score: 0.795
Data Source: STRINGDB
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
Score: 0.718
Data Source: STRINGDB
OSGIN2
Tbio
Novelty: 0.18268167
Score: 0.716
Data Source: STRINGDB
UHMK1
Tbio
Family: Kinase
Novelty: 0.04117277
Score: 0.669
Data Source: STRINGDB
CALB2
Tbio
Novelty: 0.0004996
Score: 0.656
Data Source: STRINGDB
THRSP
Tbio
Novelty: 0.00938864
Score: 0.655
Data Source: STRINGDB
CALB1
Tbio
Novelty: 0.00037716
Score: 0.629
Data Source: STRINGDB
SNRPB
Tbio
Novelty: 0.01503535
Score: 0.58
Data Source: STRINGDB
SLC4A4
Tbio
Family: Transporter
Novelty: 0.00352439
Score: 0.577
Data Source: STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
Score: 0.544
Data Source: STRINGDB
Publication Statistics
PubMed Score  160.47

PubMed score by year
PubTator Score  55.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer