Protein Summary
Reversible hydration of carbon dioxide. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the brain and contributes to bicarbonate driven GABAergic neuron excitation. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2018]
- ENST00000338437
- ENSP00000345659
- ENSG00000168748
- ENST00000394069
- ENSP00000377632
- CAVII
- CA-VII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.68 | ||
transcription factor | 0.68 | ||
PubMedID | 0.61 | ||
protein domain | 0.58 | ||
drug | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 166.03 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 115 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 166.03 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 115 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 942
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 18
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (18)
Active Ligands (942)
Protein-Protein Interactions (29)
Nearest Tclin Targets
Pathways (4)
Reactome (2)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Reversible hydration of carbon dioxide | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Reversible hydration of carbon dioxide | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 2 | 3 | 3 | 84.5 | |||||
high density lipoprotein cholesterol measurement | 2 | 3 | 4 | 83.3 | |||||
diastolic blood pressure | 1 | 1 | 1 | 73.7 | |||||
blood protein measurement | 1 | 1 | 1 | 58.4 | |||||
BMI-adjusted waist circumference | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 3 | 84.5 | |||||
high density lipoprotein cholesterol measurement | 4 | 83.3 | |||||
diastolic blood pressure | 1 | 73.7 | |||||
blood protein measurement | 1 | 58.4 | |||||
BMI-adjusted waist circumference | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 7 | VGNC:9074 | 740899 | |||||
Mouse | MGI:103100 | 12354 | ||||||
Rat | RGD:1306842 | 291819 | ||||||
Dog | carbonic anhydrase 7 | VGNC:38615 | 489772 | |||||
Horse | carbonic anhydrase 7 | VGNC:51145 | 100065583 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | carbonic anhydrase 7 | |||||
Horse | carbonic anhydrase 7 | |||||
Publication Statistics
PubMed Score 166.03
PubMed score by year
PubTator Score 55.52
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (6)
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0 of 0
PMID | Year | Title |
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