Protein Summary
Reversible hydration of carbon dioxide. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the brain and contributes to bicarbonate driven GABAergic neuron excitation. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2018]
- ENST00000338437
- ENSP00000345659
- ENSG00000168748
- ENST00000394069
- ENSP00000377632
- CAVII
- CA-VII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.68 | ||
transcription factor | 0.68 | ||
PubMedID | 0.61 | ||
protein domain | 0.58 | ||
drug | 0.49 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 160.47 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 115 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 160.47 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 115 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 471
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 17
Approved Drugs (17)
1 – 10 of 17
Active Ligands (471)
1 – 10 of 471
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 7 | VGNC:9074 | 740899 | |||||
Mouse | MGI:103100 | 12354 | ||||||
Rat | RGD:1306842 | 291819 | ||||||
Dog | carbonic anhydrase 7 | VGNC:38615 | 489772 | |||||
Horse | carbonic anhydrase 7 | VGNC:51145 | 100065583 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | carbonic anhydrase 7 | |||||
Horse | carbonic anhydrase 7 | |||||
Protein Structure (3 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (4)
Reactome (2)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Reversible hydration of carbon dioxide | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Reversible hydration of carbon dioxide | ||||
Gene Ontology Terms (7)
Functions (2)
Components (1)
Processes (4)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (29)
1 – 10 of 29
CYP24A1
Family: Enzyme
Novelty: 0.00107155
Score: 0.795
Data Source: STRINGDB
PTGS2
Family: Enzyme
Novelty: 0.00007089
Score: 0.718
Data Source: STRINGDB
OSGIN2
Novelty: 0.18268167
Score: 0.716
Data Source: STRINGDB
UHMK1
Family: Kinase
Novelty: 0.04117277
Score: 0.669
Data Source: STRINGDB
CALB2
Novelty: 0.0004996
Score: 0.656
Data Source: STRINGDB
THRSP
Novelty: 0.00938864
Score: 0.655
Data Source: STRINGDB
CALB1
Novelty: 0.00037716
Score: 0.629
Data Source: STRINGDB
SNRPB
Novelty: 0.01503535
Score: 0.58
Data Source: STRINGDB
SLC4A4
Family: Transporter
Novelty: 0.00352439
Score: 0.577
Data Source: STRINGDB
SLC9A1
Family: Transporter
Novelty: 0.00096678
Score: 0.544
Data Source: STRINGDB
Publication Statistics
PubMed Score 160.47
PubMed score by year
PubTator Score 55.52
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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