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Tclin
CA7
Carbonic anhydrase 7

Protein Summary
Description
Reversible hydration of carbon dioxide. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the brain and contributes to bicarbonate driven GABAergic neuron excitation. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338437
  • ENSP00000345659
  • ENSG00000168748
  • ENST00000394069
  • ENSP00000377632

Symbol
  • CAVII
  • CA-VII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
transcription factor
0.68
PubMedID
0.61
protein domain
0.58
drug
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 471
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (29)
1 – 10 of 29
CYP24A1
Tchem
Family: Enzyme
Novelty: 0.00108437
Score: 0.795
Data Source: STRINGDB
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00008134
Score: 0.718
Data Source: STRINGDB
OSGIN2
Tbio
Novelty: 0.11538462
Score: 0.716
Data Source: STRINGDB
UHMK1
Tbio
Family: Kinase
Novelty: 0.00180095
Score: 0.669
Data Source: STRINGDB
CALB2
Tbio
Novelty: 0.00068083
Score: 0.656
Data Source: STRINGDB
THRSP
Tbio
Novelty: 0.00422168
Score: 0.655
Data Source: STRINGDB
CALB1
Tbio
Novelty: 0.00045244
Score: 0.629
Data Source: STRINGDB
SNRPB
Tbio
Novelty: 0.01137048
Score: 0.58
Data Source: STRINGDB
SLC4A4
Tbio
Family: Transporter
Novelty: 0.00221797
Score: 0.577
Data Source: STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00112175
Score: 0.544
Data Source: STRINGDB
Publication Statistics
PubMed Score  220.52

PubMed score by year
PubTator Score  55.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQV
1-70
DFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAP
70-140
DGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVT
140-210
WIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
210-264
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA