Tclin CA7 Carbonic anhydrase 7

Protein Summary

Description

Reversible hydration of carbon dioxide. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the brain and contributes to bicarbonate driven GABAergic neuron excitation. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2018]

Uniprot Accession IDs

• P43166
• Q541F0
• Q86YU0

Gene Name

• CA7

Ensembl ID

• ENST00000338437
• ENSP00000345659
• ENSG00000168748
• ENST00000394069
• ENSP00000377632

Symbol

• CAVII
• CA-VII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
transcription factor	0.68
PubMedID	0.61
protein domain	0.58
drug	0.49

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.52   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 115   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.52   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 471

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17

Approved Drugs (17)

Explore Approved Drugs

1 – 10 of 17

acetazolamide

CA7Tclin Enzyme

Ki: 8.60000038

ethoxzolamide

CA7Tclin Enzyme

INHIBITOR Kd: 9.15

topiramate

CA7Tclin Enzyme

Ki: 9.05000019

dichlorphenamide

CA7Tclin Enzyme

Ki: 8.22

dorzolamide

CA7Tclin Enzyme

Ki: 8.46000004

brinzolamide

CA7Tclin Enzyme

Ki: 8.55000019

imatinib

CA7Tclin Enzyme

Ki: 6.96

sulpiride

CA7Tclin Enzyme

Ki: 5.44000006

nilotinib

CA7Tclin Enzyme

Ki: 7

indapamide

CA7Tclin Enzyme

Ki: 9.64

Active Ligands (471)

Explore Active Ligands

1 – 10 of 471

CHEMBL19

CA7Tclin Enzyme

Ki: 8.68

CHEMBL77517

CA7Tclin Enzyme

Ki: 6.90999985

CHEMBL750

CA7Tclin Enzyme

Ki: 6.93

CHEMBL21

CA7Tclin Enzyme

Ki: 7.16

CHEMBL73962

CA7Tclin Enzyme

Ki: 9.35

CHEMBL6633

CA7Tclin Enzyme

Ki: 8.17

CHEMBL266026

CA7Tclin Enzyme

Ki: 8.25

CHEMBL7146

CA7Tclin Enzyme

Ki: 8.19

CHEMBL265674

CA7Tclin Enzyme

Ki: 8.28

CHEMBL7087

CA7Tclin Enzyme

Ki: 7.1

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (4)

Reactome (2)

KEGG (2)

Metabolism (R-HSA-1430728)

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Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Gene Ontology Terms (7)

Functions (2)

Components (1)

Processes (4)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
carbonate dehydratase activity	Traceable Author Statement (TAS)	Reactome
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (29)

Explore Interacting Targets

1 – 10 of 29

• See Interactions on String-DB

CYP24A1

Tchem

Family: Enzyme

Novelty: 0.00108437

Score: 0.795

Data Source: STRINGDB

PTGS2

Tclin

Family: Enzyme

Novelty: 0.00008134

Score: 0.718

Data Source: STRINGDB

OSGIN2

Tbio

Novelty: 0.11538462

Score: 0.716

Data Source: STRINGDB

UHMK1

Tbio

Family: Kinase

Novelty: 0.00180095

Score: 0.669

Data Source: STRINGDB

CALB2

Tbio

Novelty: 0.00068083

Score: 0.656

Data Source: STRINGDB

THRSP

Tbio

Novelty: 0.00422168

Score: 0.655

Data Source: STRINGDB

CALB1

Tbio

Novelty: 0.00045244

Score: 0.629

Data Source: STRINGDB

SNRPB

Tbio

Novelty: 0.01137048

Score: 0.58

Data Source: STRINGDB

SLC4A4

Tbio

Family: Transporter

Novelty: 0.00221797

Score: 0.577

Data Source: STRINGDB

SLC9A1

Tchem

Family: Transporter

Novelty: 0.00112175

Score: 0.544

Data Source: STRINGDB

Publication Statistics

PubMed Score  220.52

PubMed score by year

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PubTator Score  55.52

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQV

1-70

DFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAP

70-140

DGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVT

140-210

WIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA

210-264

MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Lyase
Metal-binding
Reference proteome
Zinc