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Tbio
CRAT
Carnitine O-acetyltransferase

Protein Summary
Description
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. May be specific for short chain fatty acids. This gene encodes carnitine O-acetyltransferase, a member of the carnitine acyltransferase family and a key metabolic pathway enzyme which plays an important role in energy homeostasis and fat metabolism. This enzyme catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. It is found in both the mitochondria and the peroxisome. Alternative splicing results in transcript variants encoding different isoforms that may localize to different subcellular compartments. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318080
  • ENSP00000315013
  • ENSG00000095321

Symbol
  • CAT1
  • CAT
  • CAT1
  • NBIA8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor perturbation
0.84
histone modification site profile
0.83
cellular component
0.8
PubMedID
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.01   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.01   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
RGS3
Tbio
Novelty:  0.01749541
p_int:  1
Score:  0.187
Data Source:  BioPlex,STRINGDB
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.999999963
p_ni:  3.7e-8
Data Source:  BioPlex
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999968039
p_ni:  0.000031954
p_wrong:  7e-9
Score:  0.194
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.999868245
p_ni:  0.000104065
p_wrong:  0.00002769
Data Source:  BioPlex
CDK11B
Tchem
Family:  Kinase
Novelty:  0.02711308
p_int:  0.998216486
p_ni:  0.001783514
Data Source:  BioPlex
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.765749094
p_ni:  0.234121351
p_wrong:  0.000129554
Data Source:  BioPlex
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.989
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.966
Data Source:  STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.962
Data Source:  STRINGDB
CPT2
Tchem
Family:  Enzyme
Novelty:  0.00345645
Score:  0.961
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Beta-oxidation of pristanoyl-CoA (R-HSA-389887)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of pristanoyl-CoA
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of pristanoyl-CoA
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
6
9
98.5
red blood cell distribution width
4
3
4
95.2
urinary metabolite measurement
1
1
1
61.4
red blood cell density measurement
1
1
1
53.3
systolic blood pressure
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
9
98.5
red blood cell distribution width
4
95.2
urinary metabolite measurement
1
61.4
red blood cell density measurement
1
53.3
systolic blood pressure
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carnitine O-acetyltransferase
VGNC:4664
107976794
Macaque
carnitine O-acetyltransferase
716908
Mouse
MGI:109501
12908
Rat
RGD:1303031
311849
Dog
carnitine O-acetyltransferase
VGNC:39592
491304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carnitine O-acetyltransferase
Macaque
carnitine O-acetyltransferase
Mouse
Rat
Dog
carnitine O-acetyltransferase
Publication Statistics
PubMed Score 62.01
PubMed score by year
PubTator Score 20.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title