Pharos : Target Details

Tbio

Protein Summary

Description

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, O ...more

Uniprot Accession IDs

P43146

Gene Name

Ensembl ID

ENST00000442544
ENSP00000389140
ENSG00000187323

Symbol

IGDCC1
CRC18
CRCR1
MRMV1
HGPPS2
IGDCC1
NTN1R1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1

protein domain	0.92

biological process	0.89

phenotype	0.78

virus perturbation	0.76

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.16 (req: < 5)

View Publications

Gene RIFs: 72 (req: <= 3)

View Gene RIFs

Antibodies: 266 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.16 (req: >= 5)

Gene RIFs: 72 (req: > 3)

Antibodies: 266 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (30)

Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 30

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
unipolar depression	EFO_0003761	6	15	6	5.9	99.3

self reported educational attainment	EFO_0004784	5	7	7	6.5	99.3

mathematical ability	EFO_0004875	4	5	7		98.9

cognitive function measurement	EFO_0008354	3	3	5		98.5

smoking status measurement	EFO_0006527	3	4	5	1	98.2

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 30

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
unipolar depression	EFO_0003761	6	5.9	99.3

self reported educational attainment	EFO_0004784	7	6.5	99.3

mathematical ability	EFO_0004875	7		98.9

cognitive function measurement	EFO_0008354	5		98.5

smoking status measurement	EFO_0006527	5	1	98.2

Beta Count

Odds Ratio

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID
Chimp	DCC netrin 1 receptor	VGNC:13254	455425

Macaque	DCC netrin 1 receptor		693352

Mouse	deleted in colorectal carcinoma	MGI:94869	13176

Rat	DCC netrin 1 receptor	RGD:2492	25311

Dog	DCC netrin 1 receptor	VGNC:39799	483976

Species	Name	OMA	EggNOG	Inparanoid
Chimp	DCC netrin 1 receptor

Macaque	DCC netrin 1 receptor

Mouse	deleted in colorectal carcinoma

Rat	DCC netrin 1 receptor

Dog	DCC netrin 1 receptor

Protein Structure (9 Structures, 1 AlphaFold Model)

1 – 5 of 9

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (122)

Reactome (13)

KEGG (3)

PathwayCommons (3)

WikiPathways (103)

Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 13

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581

Reactome	Axon guidance	533 targets	R-HSA-422475

Reactome	Caspase activation via Dependence Receptors in the absence of ligand	10 targets	R-HSA-418889

Reactome	Caspase activation via extrinsic apoptotic signalling pathway	26 targets	R-HSA-5357769

Reactome	DCC mediated attractive signaling	14 targets	R-HSA-418885

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581

Axon guidance	533 targets	R-HSA-422475

Caspase activation via Dependence Receptors in the absence of ligand	10 targets	R-HSA-418889

Caspase activation via extrinsic apoptotic signalling pathway	26 targets	R-HSA-5357769

DCC mediated attractive signaling	14 targets	R-HSA-418885

Gene Ontology Terms (21)

Functions (2)

Components (5)

Processes (14)

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
transmembrane signaling receptor activity	Traceable Author Statement (TAS)	ProtInc

netrin receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (110)

1 – 10 of 110

See Interactions on String-DB

NTN1

Tbio

Novelty: 0.00183678

Score: 0.998