Protein Summary
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, O ...more
- ENST00000442544
- ENSP00000389140
- ENSG00000187323
- IGDCC1
- CRC18
- CRCR1
- MRMV1
- HGPPS2
- IGDCC1
- NTN1R1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
protein domain | 0.92 | ||
biological process | 0.89 | ||
phenotype | 0.78 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.91 (req: < 5)
Gene RIFs: 72 (req: <= 3)
Antibodies: 266 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.91 (req: >= 5)
Gene RIFs: 72 (req: > 3)
Antibodies: 266 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (110)
Nearest Tclin Targets
Pathways (122)
Reactome (13)
KEGG (3)
PathwayCommons (3)
WikiPathways (103)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Axon guidance | ||||
Reactome | Caspase activation via Dependence Receptors in the absence of ligand | ||||
Reactome | Caspase activation via extrinsic apoptotic signalling pathway | ||||
Reactome | DCC mediated attractive signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Axon guidance | ||||
Caspase activation via Dependence Receptors in the absence of ligand | ||||
Caspase activation via extrinsic apoptotic signalling pathway | ||||
DCC mediated attractive signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (2)
Components (5)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (35)
Items per page:
1 – 5 of 35
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 16 | 7 | 5.9 | 95.8 | |||||
self reported educational attainment | 5 | 7 | 7 | 6.5 | 95.4 | ||||
mathematical ability | 4 | 5 | 7 | 92.9 | |||||
smoking status measurement | 3 | 4 | 5 | 1 | 90.9 | ||||
neuroticism measurement | 5 | 14 | 8 | 5.7 | 90.9 | ||||
Items per page:
1 – 5 of 35
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
7 | 5.9 | 95.8 | |||||
self reported educational attainment | 7 | 6.5 | 95.4 | ||||
mathematical ability | 7 | 92.9 | |||||
smoking status measurement | 5 | 1 | 90.9 | ||||
neuroticism measurement | 8 | 5.7 | 90.9 | ||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DCC netrin 1 receptor | VGNC:13254 | 455425 | |||||
Macaque | DCC netrin 1 receptor | 693352 | ||||||
Mouse | MGI:94869 | 13176 | ||||||
Rat | RGD:2492 | 25311 | ||||||
Dog | DCC netrin 1 receptor | VGNC:39799 | 483976 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DCC netrin 1 receptor | |||||
Macaque | DCC netrin 1 receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | DCC netrin 1 receptor | |||||
Publication Statistics
PubMed Score 58.91
PubMed score by year
PubTator Score 437.59
PubTator score by year
Related Publications
Text Mined References (120)
GeneRif Annotations (72)
Items per page:
0 of 0
PMID | Year | Title |
|---|