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Tbio
DCC
Netrin receptor DCC

Protein Summary
Description
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, O ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442544
  • ENSP00000389140
  • ENSG00000187323

Symbol
  • IGDCC1
  • CRC18
  • CRCR1
  • MRMV1
  • HGPPS2
  • IGDCC1
  • NTN1R1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.92
biological process
0.89
phenotype
0.78
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.16   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.16   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
6
15
6
5.9
99.3
self reported educational attainment
5
7
7
6.5
99.3
mathematical ability
4
5
7
98.9
cognitive function measurement
3
3
5
98.5
smoking status measurement
3
4
5
1
98.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
6
5.9
99.3
self reported educational attainment
7
6.5
99.3
mathematical ability
7
98.9
cognitive function measurement
5
98.5
smoking status measurement
5
1
98.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DCC netrin 1 receptor
VGNC:13254
455425
Macaque
DCC netrin 1 receptor
693352
Mouse
MGI:94869
13176
Rat
RGD:2492
25311
Dog
DCC netrin 1 receptor
VGNC:39799
483976
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DCC netrin 1 receptor
Macaque
DCC netrin 1 receptor
Mouse
Rat
Dog
DCC netrin 1 receptor
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P43146-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (122)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Axon guidance
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
DCC mediated attractive signaling
Name
Explore in Pharos
Explore in Source
Apoptosis
Axon guidance
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
DCC mediated attractive signaling
Protein-Protein Interactions (110)
1 – 10 of 110
NTN1
Tbio
Novelty: 0.00183678
Score: 0.998
Data Source: Reactome,STRINGDB
MYO10
Tbio
Novelty: 0.0233015
Score: 0.984
Data Source: Reactome,STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.983
Data Source: Reactome,STRINGDB
UNC5C
Tbio
Novelty: 0.02045906
Score: 0.978
Data Source: Reactome,STRINGDB
UNC5A
Tbio
Novelty: 0.03749855
Score: 0.976
Data Source: Reactome,STRINGDB
UNC5B
Tbio
Novelty: 0.01474065
Score: 0.975
Data Source: Reactome,STRINGDB
NTN4
Tbio
Novelty: 0.03056042
Score: 0.973
Data Source: Reactome,STRINGDB
SLIT2
Tbio
Novelty: 0.00710401
Score: 0.969
Data Source: Reactome,STRINGDB
SLIT1
Tbio
Novelty: 0.01255624
Score: 0.966
Data Source: Reactome,STRINGDB
SLIT3
Tbio
Novelty: 0.00465012
Score: 0.966
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  57.16

PubMed score by year
PubTator Score  437.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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