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Tbio
MCAM
Cell surface glycoprotein MUC18

Protein Summary
Description
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264036
  • ENSP00000264036
  • ENSG00000076706

Symbol
  • MUC18
  • CD146
  • MUC18
  • HEMCAM
  • METCAM
  • MelCAM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
PubMedID
0.98
transcription factor perturbation
0.98
disease perturbation
0.96
disease
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 884.15   (req: < 5)
Gene RIFs: 137   (req: <= 3)
Antibodies: 1686   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 884.15   (req: >= 5)
Gene RIFs: 137   (req: > 3)
Antibodies: 1686   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
5
5
6.3
97.2
platelet crit
2
2
2
90.5
urate measurement
4
3
4
86.3
reticulocyte count
6
1
6
76.4
reticulocyte measurement
2
1
2
74.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
6.3
97.2
platelet crit
2
90.5
urate measurement
4
86.3
reticulocyte count
6
76.4
reticulocyte measurement
2
74.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melanoma cell adhesion molecule
VGNC:1109
744688
Macaque
melanoma cell adhesion molecule
708449
Mouse
MGI:1933966
84004
Rat
RGD:620463
78967
Dog
melanoma cell adhesion molecule
489368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melanoma cell adhesion molecule
Macaque
melanoma cell adhesion molecule
Mouse
Rat
Dog
melanoma cell adhesion molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P43121-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (110)
1 – 10 of 110
LAMA4
Tbio
Novelty:  0.01288371
p_int:  0.999997976
p_ni:  0.000002023
Score:  0.861
Data Source:  BioPlex,STRINGDB
CST5
Tbio
Novelty:  0.04273227
p_int:  0.999996857
p_ni:  0.000003114
p_wrong:  2.9e-8
Data Source:  BioPlex
CNTN1
Tbio
Novelty:  0.00741212
p_int:  0.997079633
p_ni:  0.002920367
Score:  0.21
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.964877738
p_ni:  0.035122262
Score:  0.565
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.947653323
p_ni:  0.003489095
p_wrong:  0.048857583
Score:  0.536
Data Source:  BioPlex,STRINGDB
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
p_int:  0.877322856
p_ni:  0.122677144
Score:  0.733
Data Source:  BioPlex,STRINGDB
ENG
Tbio
Novelty:  0.00036729
Score:  0.874
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.857
Data Source:  STRINGDB
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
Score:  0.843
Data Source:  STRINGDB
CD34
Tbio
Novelty:  0.00005468
Score:  0.818
Data Source:  STRINGDB
Publication Statistics
PubMed Score  884.15

PubMed score by year
PubTator Score  449.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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