Protein Summary
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
- ENST00000291294
- ENSP00000291294
- ENSG00000160013
- PRIPR
- IP
- PRIPR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 0.76 | ||
biological process | 0.73 | ||
tissue sample | 0.68 | ||
tissue | 0.67 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.48 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 240 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.48 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 240 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 188
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (188)
Protein-Protein Interactions (221)
SLC12A6
Family: Transporter
Novelty: 0.0132619
p_int: 0.999958755
p_ni: 0.000041245
Data Source: BioPlex
SLC6A8
Family: Transporter
Novelty: 0.00332655
p_int: 0.999889997
p_ni: 0.000104214
p_wrong: 0.000005789
Score: 0.36
Data Source: BioPlex,STRINGDB
UGCG
Family: Enzyme
Novelty: 0.00481791
p_int: 0.998647558
p_ni: 0.000961367
p_wrong: 0.000391075
Data Source: BioPlex
PCDH10
Novelty: 0.01058382
p_int: 0.998612064
p_ni: 0.0013867
p_wrong: 0.000001236
Data Source: BioPlex
FZD2
Family: GPCR
Novelty: 0.00774893
p_int: 0.998081501
p_ni: 0.001906689
p_wrong: 0.00001181
Data Source: BioPlex
SLC30A1
Family: Transporter
Novelty: 0.00528427
p_int: 0.997500456
p_ni: 0.002499544
Data Source: BioPlex
ANO5
Novelty: 0.01237979
p_int: 0.996752638
p_ni: 0.000009014
p_wrong: 0.003238348
Score: 0.239
Data Source: BioPlex,STRINGDB
GJC1
Novelty: 0.00375192
p_int: 0.994496027
p_ni: 0.003795644
p_wrong: 0.001708328
Score: 0.164
Data Source: BioPlex,STRINGDB
SLC15A4
Family: Transporter
Novelty: 0.01325014
p_int: 0.992249258
p_ni: 0.007726707
p_wrong: 0.000024036
Data Source: BioPlex
Nearest Tclin Targets
Pathways (19)
Reactome (11)
KEGG (3)
PathwayCommons (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Eicosanoid ligand-binding receptors | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
Eicosanoid ligand-binding receptors | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (3)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 1 | 1 | 1 | 80.9 | |||||
heel bone mineral density | 2 | 1 | 2 | 62.1 | |||||
2 | 2 | 0 | 1.2 | 60.8 | |||||
reticulocyte count | 1 | 1 | 1 | 55.2 | |||||
2 | 1 | 0 | 1.3 | 54.4 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 1 | 80.9 | |||||
heel bone mineral density | 2 | 62.1 | |||||
0 | 1.2 | 60.8 | |||||
reticulocyte count | 1 | 55.2 | |||||
0 | 1.3 | 54.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | prostaglandin I2 receptor | 456154 | ||||||
Macaque | prostaglandin I2 receptor | 716546 | ||||||
Mouse | MGI:99535 | 19222 | ||||||
Rat | RGD:1310890 | 292661 | ||||||
Dog | prostaglandin I2 receptor | VGNC:49027 | 484429 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | prostaglandin I2 receptor | |||||
Macaque | prostaglandin I2 receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | prostaglandin I2 receptor | |||||
Publication Statistics
PubMed Score 83.48
PubMed score by year
PubTator Score 178.20
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (85)
GeneRif Annotations (54)
Items per page:
0 of 0
PMID | Year | Title |
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