Tclin PTGIR Prostacyclin receptor

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Prostacyclin Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Prostacyclin Receptor

Protein Summary

Description

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43119

Gene Name

• PTGIR

Ensembl ID

• ENST00000291294
• ENSP00000291294
• ENSG00000160013

Symbol

• PRIPR
• IP
• PRIPR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.76
biological process	0.73
tissue sample	0.68
tissue	0.67
protein domain	0.58

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.25   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 240   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.25   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 180

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6

Approved Drugs (6)

Explore Approved Drugs

1 – 6 of 6

alprostadil

PTGIRTclin GPCR

: 7.5

treprostinil

PTGIRTclin GPCR

AGONIST EC50 : 8.72

epoprostenol

PTGIRTclin GPCR

AGONIST Ki : 7.8

selexipag

PTGIRTclin GPCR

AGONIST Ki : 7.69896984

iloprost

PTGIRTclin GPCR

AGONIST EC50 : 7.75

beraprost

PTGIRTclin GPCR

AGONIST IC50 : 8.37

Active Ligands (180)

Explore Active Ligands

1 – 10 of 180

CHEMBL521784

PTGIRTclin GPCR

: 4.2

carbacyclin

PTGIRTclin GPCR

: 7

iloprost

PTGIRTclin GPCR

: 8

CHEMBL3804978

PTGIRTclin GPCR

EC50 : 7.96

CHEMBL1628262

PTGIRTclin GPCR

IC50 : 7.6

cicaprost

PTGIRTclin GPCR

: 8

TG6-129

PTGIRTclin GPCR

KB : 6.69999981

CHEMBL3805134

PTGIRTclin GPCR

EC50 : 7.33

MRE-269

PTGIRTclin GPCR

Ki : 7.69999981

isocarbacyclin

PTGIRTclin GPCR

: 7.8

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ulcerative colitis	EFO_0000729	1	1	0	1.1	41.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ulcerative colitis	EFO_0000729	0	1.1	41.7

Reset Zoom  Beta Count   Odds Ratio

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	prostaglandin I2 receptor		456154
Macaque	prostaglandin I2 receptor		716546
Mouse	prostaglandin I receptor (IP)	MGI:99535	19222
Rat	prostaglandin I2 receptor	RGD:1310890	292661
Dog	prostaglandin I2 receptor	VGNC:49027	484429

Species	Name	OMA	EggNOG	Inparanoid
Chimp	prostaglandin I2 receptor
Macaque	prostaglandin I2 receptor
Mouse	prostaglandin I receptor (IP)
Rat	prostaglandin I2 receptor
Dog	prostaglandin I2 receptor

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P43119-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)

Reactome (11)

KEGG (3)

PathwayCommons (1)

WikiPathways (4)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	Eicosanoid ligand-binding receptors	15 targets	R-HSA-391903
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Eicosanoid ligand-binding receptors	15 targets	R-HSA-391903
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792

Gene Ontology Terms (14)

Functions (2)

Components (3)

Processes (9)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (221)

Explore Interacting Targets

1 – 10 of 221

• See Interactions on String-DB

SLC12A6

Tbio

Family: Transporter

Novelty: 0.0132619

p_int: 0.999958755

p_ni: 0.000041245

Data Source: BioPlex

SLC6A8

Tbio

Family: Transporter

Novelty: 0.00332655

p_int: 0.999889997

p_ni: 0.000104214

p_wrong: 0.000005789

Score: 0.36

Data Source: BioPlex,STRINGDB

PKD2

Tchem

Family: IC

Novelty: 0.00305329

p_int: 0.999120623

p_ni: 0.000879377

Data Source: BioPlex

UGCG

Tclin

Family: Enzyme

Novelty: 0.00481791

p_int: 0.998647558

p_ni: 0.000961367

p_wrong: 0.000391075

Data Source: BioPlex

PCDH10

Tbio

Novelty: 0.01058382

p_int: 0.998612064

p_ni: 0.0013867

p_wrong: 0.000001236

Data Source: BioPlex

FZD2

Tbio

Family: GPCR

Novelty: 0.00774893

p_int: 0.998081501

p_ni: 0.001906689

p_wrong: 0.00001181

Data Source: BioPlex

SLC30A1

Tbio

Family: Transporter

Novelty: 0.00528427

p_int: 0.997500456

p_ni: 0.002499544

Data Source: BioPlex

ANO5

Tbio

Novelty: 0.01237979

p_int: 0.996752638

p_ni: 0.000009014

p_wrong: 0.003238348

Score: 0.239

Data Source: BioPlex,STRINGDB

GJC1

Tbio

Novelty: 0.00375192

p_int: 0.994496027

p_ni: 0.003795644

p_wrong: 0.001708328

Score: 0.164

Data Source: BioPlex,STRINGDB

SLC15A4

Tbio

Family: Transporter

Novelty: 0.01325014

p_int: 0.992249258

p_ni: 0.007726707

p_wrong: 0.000024036

Data Source: BioPlex

Publication Statistics

PubMed Score  83.25

PubMed score by year

Reset Zoom

PubTator Score  178.2

PubTator score by year

Reset Zoom

Patents

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Methylation
Palmitate
Polymorphism

GWAS Trait Find Similar Targets

ulcerative colitis

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging