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Tclin
PTGIR
Prostacyclin receptor

Protein Summary
Description
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291294
  • ENSP00000291294
  • ENSG00000160013

Symbol
  • PRIPR
  • IP
  • PRIPR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.76
biological process
0.73
tissue sample
0.68
tissue
0.67
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.25   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.25   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 180
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
41.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
41.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin I2 receptor
456154
Macaque
prostaglandin I2 receptor
716546
Mouse
MGI:99535
19222
Rat
RGD:1310890
292661
Dog
prostaglandin I2 receptor
VGNC:49027
484429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin I2 receptor
Macaque
prostaglandin I2 receptor
Mouse
Rat
Dog
prostaglandin I2 receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P43119-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (221)
1 – 10 of 221
SLC12A6
Tbio
Family: Transporter
Novelty: 0.0132619
p_int: 0.999958755
p_ni: 0.000041245
Data Source: BioPlex
SLC6A8
Tbio
Family: Transporter
Novelty: 0.00332655
p_int: 0.999889997
p_ni: 0.000104214
p_wrong: 0.000005789
Score: 0.36
Data Source: BioPlex,STRINGDB
PKD2
Tchem
Family: IC
Novelty: 0.00305329
p_int: 0.999120623
p_ni: 0.000879377
Data Source: BioPlex
UGCG
Tclin
Family: Enzyme
Novelty: 0.00481791
p_int: 0.998647558
p_ni: 0.000961367
p_wrong: 0.000391075
Data Source: BioPlex
PCDH10
Tbio
Novelty: 0.01058382
p_int: 0.998612064
p_ni: 0.0013867
p_wrong: 0.000001236
Data Source: BioPlex
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
p_int: 0.998081501
p_ni: 0.001906689
p_wrong: 0.00001181
Data Source: BioPlex
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
p_int: 0.997500456
p_ni: 0.002499544
Data Source: BioPlex
ANO5
Tbio
Novelty: 0.01237979
p_int: 0.996752638
p_ni: 0.000009014
p_wrong: 0.003238348
Score: 0.239
Data Source: BioPlex,STRINGDB
GJC1
Tbio
Novelty: 0.00375192
p_int: 0.994496027
p_ni: 0.003795644
p_wrong: 0.001708328
Score: 0.164
Data Source: BioPlex,STRINGDB
SLC15A4
Tbio
Family: Transporter
Novelty: 0.01325014
p_int: 0.992249258
p_ni: 0.007726707
p_wrong: 0.000024036
Data Source: BioPlex
Publication Statistics
PubMed Score  83.25

PubMed score by year
PubTator Score  178.2

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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