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Tclin
PTGER2
Prostaglandin E2 receptor EP2 subtype

Protein Summary
Description
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245457
  • ENSP00000245457
  • ENSG00000125384

Symbol
  • EP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.87
PubMedID
0.84
gene perturbation
0.82
biological term
0.81
cell type or tissue
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.15   (req: < 5)
Gene RIFs: 111   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.15   (req: >= 5)
Gene RIFs: 111   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 194
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E receptor 2
VGNC:3332
467459
Macaque
prostaglandin E receptor 2
708024
Mouse
MGI:97794
19217
Rat
RGD:620020
81752
Dog
prostaglandin E receptor 2
VGNC:45143
403797
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E receptor 2
Macaque
prostaglandin E receptor 2
Mouse
Rat
Dog
prostaglandin E receptor 2
Pathways (18)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (152)
1 – 10 of 152
GNG2
Tbio
Novelty: 0.04807242
Score: 0.94
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.932
Data Source: STRINGDB
ADRB2
Tclin
Family: GPCR
Novelty: 0.00041821
Score: 0.93
Data Source: STRINGDB
PTGER4
Tclin
Family: GPCR
Novelty: 0.0008127
Score: 0.927
Data Source: STRINGDB
LHCGR
Tclin
Family: GPCR
Novelty: 0.00169974
Score: 0.923
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.922
Data Source: STRINGDB
ADCY4
Tbio
Family: Enzyme
Novelty: 0.00465974
Score: 0.922
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00307839
Score: 0.92
Data Source: STRINGDB
ADORA2B
Tclin
Family: GPCR
Novelty: 0.00096284
Score: 0.92
Data Source: STRINGDB
RAMP1
Tclin
Novelty: 0.00831253
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.15

PubMed score by year
PubTator Score  340.09

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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