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Tclin
PTGER3
Prostaglandin E2 receptor EP3 subtype

Protein Summary
Description
Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306666
  • ENSP00000302313
  • ENSG00000050628
  • ENST00000351052
  • ENSP00000280208
  • ENST00000356595
  • ENSP00000349003
  • ENST00000370924
  • ENSP00000359962
  • ENST00000370931
  • ENSP00000359969
  • ENST00000460330
  • ENSP00000418073
  • ENST00000479353
  • ENSP00000421583
  • ENST00000628037
  • ENSP00000486617

Symbol
  • EP3
  • EP3e
  • EP3-I
  • EP3-II
  • EP3-IV
  • EP3-VI
  • PGE2-R
  • EP3-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
ligand (chemical)
0.97
disease perturbation
0.95
microRNA
0.87
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.8   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 420   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.8   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 414
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
3
3
91.1
smoking status measurement
2
1
2
82.9
self reported educational attainment
1
1
1
66.3
intelligence
1
1
1
17.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
91.1
smoking status measurement
2
82.9
self reported educational attainment
1
66.3
intelligence
1
17.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E receptor 3
VGNC:6129
456940
Macaque
prostaglandin E receptor 3
703398
Mouse
MGI:97795
19218
Rat
RGD:3435
24929
Horse
prostaglandin E receptor 3
VGNC:21988
100053557
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E receptor 3
Macaque
prostaglandin E receptor 3
Mouse
Rat
Horse
prostaglandin E receptor 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P43115-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (332)
1 – 10 of 332
TMED8
Tdark
Novelty: 1.41977071
p_int: 0.99994186
p_ni: 0.000058135
p_wrong: 5e-9
Data Source: BioPlex
PLCB1
Tbio
Family: Enzyme
Novelty: 0.00269771
p_int: 0.999936935
p_ni: 0.000023609
p_wrong: 0.000039456
Score: 0.23
Data Source: BioPlex,STRINGDB
PKN3
Tbio
Family: Kinase
Novelty: 0.0516816
p_int: 0.999850164
p_ni: 0.000149836
Data Source: BioPlex
RHBDF2
Tbio
Family: Enzyme
Novelty: 0.02487334
p_int: 0.999712933
p_ni: 0.000286586
p_wrong: 4.81e-7
Data Source: BioPlex
HOOK2
Tbio
Novelty: 0.03559628
p_int: 0.999580914
p_ni: 0.000419086
Data Source: BioPlex
CWC22
Tbio
Novelty: 0.027689
p_int: 0.999327127
p_ni: 0.000672872
Data Source: BioPlex
PPP1R15B
Tbio
Family: Enzyme
Novelty: 0.0244819
p_int: 0.999306246
p_ni: 0.00069156
p_wrong: 0.000002194
Data Source: BioPlex
MYADM
Tbio
Novelty: 0.11475375
p_int: 0.999124332
p_ni: 0.000873849
p_wrong: 0.000001819
Data Source: BioPlex
TYW1B
Tdark
Family: Enzyme
Novelty: 0.86504466
p_int: 0.999107412
p_ni: 0.000892588
Data Source: BioPlex
ANKRD13D
Tdark
Novelty: 2.14380936
p_int: 0.998559608
p_ni: 0.001440391
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  794.80

PubMed score by year
PubTator Score  223.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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