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Tclin
PTGER3
Prostaglandin E2 receptor EP3 subtype

Protein Summary
Description
Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306666
  • ENSP00000302313
  • ENSG00000050628
  • ENST00000351052
  • ENSP00000280208
  • ENST00000356595
  • ENSP00000349003
  • ENST00000370924
  • ENSP00000359962
  • ENST00000370931
  • ENSP00000359969
  • ENST00000460330
  • ENSP00000418073
  • ENST00000479353
  • ENSP00000421583
  • ENST00000628037
  • ENSP00000486617

Symbol
  • EP3
  • EP3e
  • EP3-I
  • EP3-II
  • EP3-IV
  • EP3-VI
  • PGE2-R
  • EP3-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
ligand (chemical)
0.97
disease perturbation
0.95
microRNA
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.33   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 420   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.33   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 545
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5