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Tclin
PTGFR
Prostaglandin F2-alpha receptor

Protein Summary
Description
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding diff ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370756
  • ENSP00000359792
  • ENSG00000122420
  • ENST00000370757
  • ENSP00000359793
  • ENST00000370758
  • ENSP00000359794

Symbol
  • FP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
cell type or tissue
0.8
ligand (chemical)
0.8
disease perturbation
0.68
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.05   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.05   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 53
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
59
MMR-related febrile seizures
1
1
0
1.4
52.4
Febrile seizure (within the age range of 3 months to 6 years)
1
1
0
1.4
35
skin fluorescence measurement
1
1
1
33.1
hip bone size
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
59
MMR-related febrile seizures
0
1.4
52.4
Febrile seizure (within the age range of 3 months to 6 years)
0
1.4
35
skin fluorescence measurement
1
33.1
hip bone size
1
27.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin F receptor
VGNC:6967
456970
Macaque
prostaglandin F receptor
707535
Mouse
MGI:97796
19220
Rat
RGD:3436
25652
Dog
prostaglandin F receptor
VGNC:45147
479981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin F receptor
Macaque
prostaglandin F receptor
Mouse
Rat
Dog
prostaglandin F receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P43088-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (202)
1 – 10 of 202
DNAJC5
Tbio
Novelty:  0.00091288
p_int:  0.998384324
p_ni:  0.000006229
p_wrong:  0.001609447
Score:  0.54
Data Source:  BioPlex,STRINGDB
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.997210633
p_ni:  0.00278936
p_wrong:  7e-9
Score:  0.439
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.986801865
p_ni:  0.013198135
Data Source:  BioPlex
NDFIP1
Tbio
Novelty:  0.04496467
p_int:  0.955440566
p_ni:  0.044556573
p_wrong:  0.000002861
Score:  0.185
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.934669016
p_ni:  0.065139925
p_wrong:  0.000191059
Data Source:  BioPlex
SLC20A2
Tbio
Family:  Transporter
Novelty:  0.00387767
p_int:  0.922597151
p_ni:  0.060303096
p_wrong:  0.017099753
Score:  0.523
Data Source:  BioPlex,STRINGDB
MBOAT7
Tbio
Family:  Enzyme
Novelty:  0.01861411
p_int:  0.886129117
p_ni:  0.113583176
p_wrong:  0.000287706
Data Source:  BioPlex
YIPF4
Tdark
Novelty:  0.17862058
p_int:  0.83040443
p_ni:  0.167487094
p_wrong:  0.002108476
Score:  0.167
Data Source:  BioPlex,STRINGDB
AGTR1
Tclin
Family:  GPCR
Novelty:  0.00033439
Score:  0.949
Data Source:  STRINGDB
OXTR
Tclin
Family:  GPCR
Novelty:  0.0007551
Score:  0.946
Data Source:  STRINGDB
Publication Statistics
PubMed Score  169.05

PubMed score by year
PubTator Score  80.1

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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