Tclin PTGFR Prostaglandin F2-alpha receptor

Protein Summary

Description

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43088
• A8K9Y0
• Q2KHP3
• Q6RYQ6
• Q9P1X4
• PGF receptor

Gene Name

• PTGFR

Ensembl ID

• ENST00000370756
• ENSP00000359792
• ENSG00000122420
• ENST00000370757
• ENSP00000359793
• ENST00000370758
• ENSP00000359794

Symbol

• FP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.94
cell type or tissue	0.8
ligand (chemical)	0.8
disease perturbation	0.68
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Prostaglandin F2-alpha Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Prostaglandin F2-alpha Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.05   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.05   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 77

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8