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Tbio
GUCA1A
Guanylyl cyclase-activating protein 1

Protein Summary
Description
Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:19459154). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000053469
  • ENSP00000053469
  • ENSG00000048545
  • ENST00000372958
  • ENSP00000362049
  • ENST00000394237
  • ENSP00000377784

Symbol
  • C6orf131
  • GCAP
  • GCAP1
  • GUCA1
  • COD3
  • GCAP
  • GUCA
  • GCAP1
  • GUCA1
  • CORD14
  • C6orf131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
cellular component
0.65
biological process
0.64
gene perturbation
0.58
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.54   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.54   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 1A
VGNC:11093
748651
Mouse
MGI:102770
14913
Rat
RGD:1308712
301233
Dog
guanylate cyclase activator 1A
VGNC:41561
609180
Horse
guanylate cyclase activator 1A [Source:HGNC Symbol;Acc:HGNC:4678]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 1A
Mouse
Rat
Dog
guanylate cyclase activator 1A
Horse
guanylate cyclase activator 1A [Source:HGNC Symbol;Acc:HGNC:4678]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P43080-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (120)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (91)
1 – 10 of 91
GUCY2D
Tbio
Family: Kinase
Novelty: 0.00578343
Score: 0.999
Data Source: STRINGDB
GUCY2F
Tbio
Family: Kinase
Novelty: 0.03634576
Score: 0.993
Data Source: STRINGDB
CNGA1
Tchem
Family: IC
Novelty: 0.00848214
Score: 0.962
Data Source: STRINGDB
SLC25A18
Tbio
Family: Transporter
Novelty: 0.00270676
Score: 0.962
Data Source: STRINGDB
CNGB1
Tbio
Family: IC
Novelty: 0.01034916
Score: 0.951
Data Source: STRINGDB
GUCA1B
Tbio
Family: Enzyme
Novelty: 0.02031715
Score: 0.92
Data Source: STRINGDB
SLC25A22
Tbio
Family: Transporter
Novelty: 0.05854569
Score: 0.906
Data Source: STRINGDB
GUCA1C
Tdark
Family: Enzyme
Novelty: 0.25914047
Score: 0.906
Data Source: STRINGDB
S100B
Tchem
Novelty: 0.00031007
Score: 0.893
Data Source: STRINGDB
GUCY2C
Tclin
Family: Kinase
Novelty: 0.00209733
Score: 0.82
Data Source: STRINGDB
Publication Statistics
PubMed Score  116.54

PubMed score by year
PubTator Score  84.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer