Tbio GUCA1A Guanylyl cyclase-activating protein 1

Protein Summary

Description

Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:19459154). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P43080
• B3KWT4
• Q7Z6T1
• Q9NU14
• GCAP 1

Gene Name

• GUCA1A

Ensembl ID

• ENST00000053469
• ENSP00000053469
• ENSG00000048545
• ENST00000372958
• ENSP00000362049
• ENST00000394237
• ENSP00000377784

Symbol

• C6orf131
• GCAP
• GCAP1
• GUCA1
• COD3
• GCAP
• GUCA
• GCAP1
• GUCA1
• CORD14
• C6orf131

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.8
cellular component	0.65
biological process	0.64
gene perturbation	0.58
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.21   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.21   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0