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Tbio
SLC1A4
Neutral amino acid transporter A

Protein Summary
Description
Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234256
  • ENSP00000234256
  • ENSG00000115902
  • ENST00000531327
  • ENSP00000431942

Symbol
  • ASCT1
  • SATT
  • SATT
  • ASCT1
  • SPATCCM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
1
transcription factor perturbation
0.98
kinase perturbation
0.97
virus perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.94   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.94   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
84.1
ejection fraction measurement
1
1
1
20.1
fractional shortening
1
1
1
20
left ventricular systolic function measurement
1
1
1
14.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
84.1
ejection fraction measurement
1
20.1
fractional shortening
1
20
left ventricular systolic function measurement
1
14.9
Pathways (4)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (32)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.876372287
p_ni: 0.123627693
p_wrong: 2e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
GGT5
Tbio
Family: Enzyme
Novelty: 0.00602505
p_int: 0.827067353
p_ni: 0.172932646
Score: 0.557
Data Source: BioPlex,STRINGDB
SLC38A2
Tbio
Family: Transporter
Novelty: 0.00808235
Score: 0.798
Data Source: STRINGDB
SLC7A5
Tbio
Family: Transporter
Novelty: 0.00365806
Score: 0.765
Data Source: STRINGDB
SLC7A1
Tbio
Family: Transporter
Novelty: 0.00197313
Score: 0.682
Data Source: STRINGDB
SLC38A1
Tbio
Family: Transporter
Novelty: 0.01350134
Score: 0.678
Data Source: STRINGDB
SLC7A8
Tbio
Family: Transporter
Novelty: 0.03433454
Score: 0.675
Data Source: STRINGDB
SLC7A11
Tchem
Family: Transporter
Novelty: 0.00238054
Score: 0.656
Data Source: STRINGDB
ERVW-1
Tbio
Novelty: 0.00038992
Score: 0.651
Data Source: STRINGDB
SLC7A6
Tbio
Family: Transporter
Novelty: 0.02732334
Score: 0.646
Data Source: STRINGDB
Publication Statistics
PubMed Score  75.94

PubMed score by year
PubTator Score  38.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer