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Tchem
SLC1A1
Excitatory amino acid transporter 3

Protein Summary
Description
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Negatively regulated by ARL6IP5 (By similar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262352
  • ENSP00000262352
  • ENSG00000106688

Symbol
  • EAAC1
  • EAAT3
  • DCBXA
  • EAAC1
  • EAAT3
  • SCZD18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
PubMedID
0.97
transcription factor perturbation
0.84
disease perturbation
0.79
virus perturbation
0.79


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.6   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.6   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
glutamic acid
chemical structure image
Active Ligands (21)
1 – 10 of 21
CHEMBL79140
chemical structure image
[<sup>3</sup>H]ETB-TBOA
chemical structure image
CHEMBL2113123
chemical structure image
CHEMBL425569
chemical structure image
CHEMBL2113126
chemical structure image
CHEMBL2113113
chemical structure image
CHEMBL424838
chemical structure image
CHEMBL2113117
chemical structure image
CHEMBL1628570
chemical structure image
CHEMBL2113111
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
5.1
66.3
response to antipsychotic drug
1
1
0
3.4
40.5
response to risperidone
1
1
0
6.8
37.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.1
66.3
response to antipsychotic drug
0
3.4
40.5
response to risperidone
0
6.8
37.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 1 member 1
VGNC:8928
464974
Macaque
solute carrier family 1 member 1
694947
Mouse
MGI:105083
20510
Rat
RGD:3696
25550
Dog
solute carrier family 1 member 1
VGNC:46261
403751
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 1 member 1
Macaque
solute carrier family 1 member 1
Mouse
Rat
Dog
solute carrier family 1 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P43005-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) (R-HSA-5619067)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Disease
Disorders of transmembrane transporters
Glutamate Neurotransmitter Release Cycle
Neuronal System
Gene Ontology Terms (25)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (139)
1 – 10 of 139
NUMBL
Tbio
Novelty: 0.01383607
p_int: 0.999998807
p_ni: 0.000001157
p_wrong: 3.6e-8
Score: 0.195
Data Source: BioPlex,STRINGDB
CC2D1A
Tbio
Novelty: 0.01970021
p_int: 0.99999014
p_ni: 0.000005717
p_wrong: 0.000004143
Data Source: BioPlex
FMC1
Tbio
Novelty: 0.06702205
p_int: 0.999638614
p_ni: 0.000162539
p_wrong: 0.000198846
Data Source: BioPlex
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999492664
p_ni: 0.000466191
p_wrong: 0.000041145
Score: 0.26
Data Source: BioPlex,STRINGDB
SNX3
Tbio
Novelty: 0.02703152
p_int: 0.999330553
p_ni: 0.000669433
p_wrong: 1.5e-8
Score: 0.159
Data Source: BioPlex,STRINGDB
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.998360738
p_ni: 0.001639255
p_wrong: 7e-9
Data Source: BioPlex
GOLGA7
Tbio
Novelty: 0.17108842
p_int: 0.998311616
p_ni: 0.001649344
p_wrong: 0.00003904
Score: 0.177
Data Source: BioPlex,STRINGDB
ORMDL3
Tbio
Novelty: 0.00958976
p_int: 0.99757306
p_ni: 0.000006192
p_wrong: 0.002420748
Data Source: BioPlex
NDFIP1
Tbio
Novelty: 0.04496467
p_int: 0.995288793
p_ni: 0.004711207
Data Source: BioPlex
NRN1
Tbio
Novelty: 0.01198116
p_int: 0.992843289
p_ni: 0.007153985
p_wrong: 0.000002726
Data Source: BioPlex
Publication Statistics
PubMed Score  494.60

PubMed score by year
PubTator Score  226.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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