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Tchem
SLC1A1
Excitatory amino acid transporter 3

Protein Summary
Description
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Negatively regulated by ARL6IP5 (By similar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262352
  • ENSP00000262352
  • ENSG00000106688

Symbol
  • EAAC1
  • EAAT3
  • DCBXA
  • EAAC1
  • EAAT3
  • SCZD18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
PubMedID
0.97
transcription factor perturbation
0.84
disease perturbation
0.79
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.19   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.19   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (29)
DL-TBOA
Rendered image for DL-TBOA
[<sup>3</sup>H]ETB-TBOA
Rendered image for [<sup>3</sup>H]ETB-TBOA
NBI-59159
Rendered image for NBI-59159
CHEMBL4177507
Rendered image for CHEMBL4177507
CHEMBL4176482
Rendered image for CHEMBL4176482
CHEMBL4176427
Rendered image for CHEMBL4176427
CHEMBL1257519
Rendered image for CHEMBL1257519
CHEMBL4165811
Rendered image for CHEMBL4165811
CHEMBL2113112
Rendered image for CHEMBL2113112
Protein-Protein Interactions (139)
NUMBL
Tbio
Novelty:  0.01383607
p_int:  0.999998807
p_ni:  0.000001157
p_wrong:  3.6e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
CC2D1A
Tbio
Novelty:  0.01970021
p_int:  0.99999014
p_ni:  0.000005717
p_wrong:  0.000004143
Data Source:  BioPlex
FMC1
Tbio
Novelty:  0.06702205
p_int:  0.999638614
p_ni:  0.000162539
p_wrong:  0.000198846
Data Source:  BioPlex
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999492664
p_ni:  0.000466191
p_wrong:  0.000041145
Score:  0.26
Data Source:  BioPlex,STRINGDB
SNX3
Tbio
Novelty:  0.02703152
p_int:  0.999330553
p_ni:  0.000669433
p_wrong:  1.5e-8
Score:  0.159
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.998360738
p_ni:  0.001639255
p_wrong:  7e-9
Data Source:  BioPlex
GOLGA7
Tbio
Novelty:  0.17108842
p_int:  0.998311616
p_ni:  0.001649344
p_wrong:  0.00003904
Score:  0.177
Data Source:  BioPlex,STRINGDB
ORMDL3
Tbio
Novelty:  0.00958976
p_int:  0.99757306
p_ni:  0.000006192
p_wrong:  0.002420748
Data Source:  BioPlex
NDFIP1
Tbio
Novelty:  0.04496467
p_int:  0.995288793
p_ni:  0.004711207
Data Source:  BioPlex
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.992843289
p_ni:  0.007153985
p_wrong:  0.000002726
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) (R-HSA-5619067)

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Find Similar Targets
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1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Disease
Disorders of transmembrane transporters
Glutamate Neurotransmitter Release Cycle
Neuronal System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
78.2
platelet crit
1
1
1
51.4
neutrophil count
1
1
1
37.6
response to antipsychotic drug
1
1
0
3.4
33.1
hip circumference
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
78.2
platelet crit
1
51.4
neutrophil count
1
37.6
response to antipsychotic drug
0
3.4
33.1
hip circumference
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 1 member 1
VGNC:8928
464974
Macaque
solute carrier family 1 member 1
694947
Mouse
MGI:105083
20510
Rat
RGD:3696
25550
Dog
solute carrier family 1 member 1
VGNC:46261
403751
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 1 member 1
Macaque
solute carrier family 1 member 1
Mouse
Rat
Dog
solute carrier family 1 member 1
Publication Statistics
PubMed Score 501.19
PubMed score by year
PubTator Score 226.23
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title