SLC1A1
Excitatory amino acid transporter 3
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
PubMedID | 0.97 | ||
transcription factor perturbation | 0.84 | ||
disease perturbation | 0.79 | ||
virus perturbation | 0.79 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Reactome | Glutamate Neurotransmitter Release Cycle | ||||
Reactome | Neuronal System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
Glutamate Neurotransmitter Release Cycle | ||||
Neuronal System | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 2 | 2 | 78.2 | |||||
platelet crit | 1 | 1 | 1 | 51.4 | |||||
neutrophil count | 1 | 1 | 1 | 37.6 | |||||
response to antipsychotic drug | 1 | 1 | 0 | 3.4 | 33.1 | ||||
hip circumference | 1 | 1 | 1 | 21.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 78.2 | |||||
platelet crit | 1 | 51.4 | |||||
neutrophil count | 1 | 37.6 | |||||
response to antipsychotic drug | 0 | 3.4 | 33.1 | ||||
hip circumference | 1 | 21.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 1 member 1 | VGNC:8928 | 464974 | |||||
Macaque | solute carrier family 1 member 1 | 694947 | ||||||
Mouse | MGI:105083 | 20510 | ||||||
Rat | RGD:3696 | 25550 | ||||||
Dog | solute carrier family 1 member 1 | VGNC:46261 | 403751 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | solute carrier family 1 member 1 | |||||
Macaque | solute carrier family 1 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 1 member 1 | |||||
PMID | Year | Title |
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