Tchem SLC1A2 Excitatory amino acid transporter 2

Protein Summary

Description

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]

Uniprot Accession IDs

• P43004
• B4DQE9
• Q14417
• Q541G6
• U3KQQ4

Gene Name

• SLC1A2

Ensembl ID

• ENST00000278379
• ENSP00000278379
• ENSG00000110436
• ENST00000395753
• ENSP00000379102
• ENST00000643000
• ENSP00000495164
• ENST00000643305
• ENSP00000494828
• ENST00000644050
• ENSP00000496123
• ENST00000644299
• ENSP00000494669
• ENST00000645194
• ENSP00000496093
• ENST00000645634
• ENSP00000493945
• ENST00000647104
• ENSP00000494025

Symbol

• EAAT2
• GLT1
• HBGT
• EAAT2
• GLT-1
• EIEE41

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
molecular function	0.96
microRNA	0.8
disease	0.78
PubMedID	0.77

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Excitatory Amino Acid Transporter 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc1 Family Of Amino Acid Transporters / Glutamate Transporter Subfamily / Excitatory Amino Acid Transporter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1476.89   (req: < 5)

Gene RIFs: 133   (req: <= 3)

Antibodies: 265   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1476.89   (req: >= 5)

Gene RIFs: 133   (req: > 3)

Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 48

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0