Tchem SLC1A3 Excitatory amino acid transporter 1

Protein Summary

Description

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• P43003
• B2R5T3
• Q4JCQ8

Gene Name

• SLC1A3

Ensembl ID

• ENST00000265113
• ENSP00000265113
• ENSG00000079215
• ENST00000381918
• ENSP00000371343

Symbol

• EAAT1
• GLAST
• GLAST1
• EA6
• EAAT1
• GLAST
• GLAST1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
PubMedID	0.9
biological process	0.87
interacting protein	0.76
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Excitatory Amino Acid Transporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc1 Family Of Amino Acid Transporters / Glutamate Transporter Subfamily / Excitatory Amino Acid Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 888.5   (req: < 5)

Gene RIFs: 86   (req: <= 3)

Antibodies: 360   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 888.5   (req: >= 5)

Gene RIFs: 86   (req: > 3)

Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 35

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0