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Tchem
ECE1
Endothelin-converting enzyme 1

Protein Summary
Description
Converts big endothelin-1 to endothelin-1. The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264205
  • ENSP00000264205
  • ENSG00000117298
  • ENST00000357071
  • ENSP00000349581
  • ENST00000374893
  • ENSP00000364028
  • ENST00000415912
  • ENSP00000405088

Symbol
  • ECE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.9
ligand (protein) perturbation
0.83
kinase perturbation
0.76
transcription factor binding site profile
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.35   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.35   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 259
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1