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Tchem
ECE1
Endothelin-converting enzyme 1

Protein Summary
Description
Converts big endothelin-1 to endothelin-1. The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264205
  • ENSP00000264205
  • ENSG00000117298
  • ENST00000357071
  • ENSP00000349581
  • ENST00000374893
  • ENSP00000364028
  • ENST00000415912
  • ENSP00000405088

Symbol
  • ECE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.9
ligand (protein) perturbation
0.83
kinase perturbation
0.76
transcription factor binding site profile
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.14   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.14   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 259
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
racecadotril
Rendered image for racecadotril
Active Ligands (259)
1 – 10 of 259
CHEMBL570718
Rendered image for CHEMBL570718
CHEMBL570732
Rendered image for CHEMBL570732
CHEMBL577753
Rendered image for CHEMBL577753
CHEMBL305388
Rendered image for CHEMBL305388
CHEMBL43370
Rendered image for CHEMBL43370
CHEMBL570843
Rendered image for CHEMBL570843
Thiorphan
Rendered image for Thiorphan
CHEMBL4435800
Rendered image for CHEMBL4435800
CHEMBL571153
Rendered image for CHEMBL571153
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
3
2
3.6
97
basophil count
2
2
2
78.2
calcium measurement
1
1
1
70.9
body height
1
1
1
52.7
red blood cell distribution width
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
3.6
97
basophil count
2
78.2
calcium measurement
1
70.9
body height
1
52.7
red blood cell distribution width
1
44.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endothelin converting enzyme 1
VGNC:526
456594
Macaque
endothelin converting enzyme 1
706810
Mouse
MGI:1101357
230857
Rat
RGD:620293
94204
Dog
endothelin converting enzyme 1
VGNC:40181
487388
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endothelin converting enzyme 1
Macaque
endothelin converting enzyme 1
Mouse
Rat
Dog
endothelin converting enzyme 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42892-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred by Curator (IC)
BHF-UCL
Protein-Protein Interactions (58)
1 – 10 of 58
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.967194
p_ni:  0.032806
Score:  0.215
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.945106604
p_ni:  0.054893396
Score:  0.174
Data Source:  BioPlex,STRINGDB
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.919349683
p_ni:  0.080650316
p_wrong:  1e-9
Score:  0.514
Data Source:  BioPlex,STRINGDB
NPB
Tdark
Novelty:  0.00936692
p_int:  0.91301175
p_ni:  0.08698825
Score:  0.183
Data Source:  BioPlex,STRINGDB
EDDM3A
Tdark
Novelty:  0.05607223
p_int:  0.880584296
p_ni:  0.119415704
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.875761244
p_ni:  0.124238756
Score:  0.264
Data Source:  BioPlex,STRINGDB
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.864925428
p_ni:  0.135074572
Data Source:  BioPlex
FUT3
Tbio
Family:  Enzyme
Novelty:  0.0059835
p_int:  0.856644266
p_ni:  0.143355734
Score:  0.181
Data Source:  BioPlex,STRINGDB
SUSD4
Tbio
Novelty:  0.22201938
p_int:  0.824721613
p_ni:  0.175278387
Data Source:  BioPlex
SPAG11B
Tbio
Novelty:  0.07935181
p_int:  0.819079652
p_ni:  0.180920348
Data Source:  BioPlex
Publication Statistics
PubMed Score  548.14

PubMed score by year
PubTator Score  382.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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