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Tchem
PRCP
Lysosomal Pro-X carboxypeptidase

Protein Summary
Description
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313010
  • ENSP00000317362
  • ENSG00000137509
  • ENST00000393399
  • ENSP00000377055

Symbol
  • PCP
  • PCP
  • HUMPCP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.91
histone modification site profile
0.82
tissue sample
0.74
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.91   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.91   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 324
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Name
Explore in Pharos
Explore in Source
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Immune System
Innate Immune System
Intrinsic Pathway of Fibrin Clot Formation
Protein-Protein Interactions (117)
1 – 10 of 117
FBXO6
Tbio
Novelty: 0.02173918
p_int: 0.862796158
p_ni: 0.137203842
Score: 0.228
Data Source: BioPlex,STRINGDB
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.791151575
p_ni: 0.208848425
Score: 0.19
Data Source: BioPlex,STRINGDB
KLKB1
Tclin
Family: Enzyme
Novelty: 0.00109438
Score: 0.963
Data Source: Reactome,STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.956
Data Source: Reactome,STRINGDB
C1QBP
Tbio
Novelty: 0.00532825
Score: 0.938
Data Source: Reactome,STRINGDB
ACE2
Tchem
Family: Enzyme
Novelty: 0.00028408
Score: 0.924
Data Source: STRINGDB
MEP1A
Tbio
Novelty: 0.01802936
Score: 0.914
Data Source: STRINGDB
LAMP2
Tbio
Novelty: 0.00168009
Score: 0.911
Data Source: STRINGDB
SURF4
Tbio
Novelty: 0.03230108
Score: 0.91
Data Source: STRINGDB
LPCAT1
Tbio
Family: Enzyme
Novelty: 0.01441133
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  153.91

PubMed score by year
PubTator Score  269.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer