Tchem PRCP Lysosomal Pro-X carboxypeptidase

Protein Summary

Description

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P42785
• A8MU24
• B2R7B7
• B3KRK5
• B5BU34

Gene Name

• PRCP

Ensembl ID

• ENST00000313010
• ENSP00000317362
• ENSG00000137509
• ENST00000393399
• ENSP00000377055

Symbol

• PCP
• PCP
• HUMPCP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
transcription factor binding site profile	0.91
histone modification site profile	0.82
tissue sample	0.74
cellular component	0.66

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Lysosomal Pro-x Carboxypeptidase

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Lysosomal Pro-x Carboxypeptidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.14   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 230   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.14   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 324

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3