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Tbio
CDKN2B
Cyclin-dependent kinase 4 inhibitor B

Protein Summary
Description
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276925
  • ENSP00000276925
  • ENSG00000147883
  • ENST00000380142
  • ENSP00000369487

Symbol
  • MTS2
  • P15
  • MTS2
  • TP15
  • CDK4I
  • INK4B
  • p15INK4b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
biological term
0.95
PubMedID
0.9
gene perturbation
0.87
disease
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 620.3   (req: < 5)
Gene RIFs: 244   (req: <= 3)
Antibodies: 566   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 620.3   (req: >= 5)
Gene RIFs: 244   (req: > 3)
Antibodies: 566   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
1
1
75.7
1
1
0
1.3
71.3
1
1
0
1.2
65.4
1
1
1
64.2
1
1
0
1.4
46.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
75.7
0
1.3
71.3
0
1.2
65.4
1
64.2
0
1.4
46.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cyclin dependent kinase inhibitor 2B
709209
Mouse
MGI:104737
12579
Rat
RGD:2324
25164
Dog
cyclin dependent kinase inhibitor 2B
481563
Horse
cyclin-dependent kinase 2B inhibitor
100034122
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cyclin dependent kinase inhibitor 2B
Mouse
Rat
Dog
cyclin dependent kinase inhibitor 2B
Horse
cyclin-dependent kinase 2B inhibitor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P42772-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (49)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Protein-Protein Interactions (155)
1 – 10 of 155
CDK6
Tclin
Family: Kinase
Novelty: 0.00109319
p_int: 0.999999973
p_ni: 2.7e-8
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
CDK4
Tclin
Family: Kinase
Novelty: 0.00036742
p_int: 0.999999965
p_ni: 7e-9
p_wrong: 2.8e-8
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
Score: 0.979
Data Source: STRINGDB
CDKN1B
Tbio
Family: Enzyme
Novelty: 0.00069449
Score: 0.971
Data Source: STRINGDB
CDKN1C
Tbio
Family: Enzyme
Novelty: 0.00220485
Score: 0.968
Data Source: STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.967
Data Source: STRINGDB
CCND1
Tchem
Novelty: 0.0001186
Score: 0.966
Data Source: STRINGDB
CCND2
Tbio
Novelty: 0.00157305
Score: 0.961
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.951
Data Source: STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  620.30

PubMed score by year
PubTator Score  1253.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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