Tbio P42771 Cyclin-dependent kinase inhibitor 2A

Protein Summary

Description

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

Uniprot Accession IDs

• P42771
• A5X2G7
• D3DRK1
• G3XAG3
• O95440
• Q15191
• Q5VVJ5
• Q96B52
• Q9NP05

Gene Name

• CDKN2A

Ensembl ID

• ENST00000304494
• ENSP00000307101
• ENSG00000147889
• ENST00000380151
• ENSP00000369496
• ENST00000494262
• ENSP00000464952
• ENST00000498124
• ENSP00000418915
• ENST00000498628
• ENSP00000467857
• ENST00000578845
• ENSP00000467390

Symbol

• CDKN2
• MTS1
• ARF
• MLM
• P14
• P16
• P19
• CMM2
• INK4
• MTS1
• TP16
• CDK4I
• CDKN2
• INK4A
• MTS-1
• P14ARF
• P19ARF
• P16INK4
• P16INK4A
• P16-INK4A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
chemical	0.97
hub protein	0.95
biological process	0.91
cellular component	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13199.22   (req: < 5)

Gene RIFs: 2240   (req: <= 3)

Antibodies: 1199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13199.22   (req: >= 5)

Gene RIFs: 2240   (req: > 3)

Antibodies: 1199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0