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Tbio
WAS
Wiskott-Aldrich syndrome protein

Protein Summary
Description
Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376701
  • ENSP00000365891
  • ENSG00000015285

Symbol
  • IMD2
  • THC
  • IMD2
  • SCNX
  • THC1
  • WASP
  • WASPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
hub protein
0.95
kinase
0.92
protein domain
0.85
phenotype
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.42   (req: < 5)
Gene RIFs: 125   (req: <= 3)
Antibodies: 451   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.42   (req: >= 5)
Gene RIFs: 125   (req: > 3)
Antibodies: 451   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
2
2
90
eosinophil percentage of leukocytes
1
1
1
82.8
platelet count
1
1
1
57.8
mean platelet volume
1
1
1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
90
eosinophil percentage of leukocytes
1
82.8
platelet count
1
57.8
mean platelet volume
1
15.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Wiskott-Aldrich syndrome
714474
Mouse
MGI:105059
22376
Rat
RGD:1563567
317371
Dog
Wiskott-Aldrich syndrome
491867
Opossum
Wiskott-Aldrich syndrome
100018699
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Wiskott-Aldrich syndrome
Mouse
Rat
Dog
Wiskott-Aldrich syndrome
Opossum
Wiskott-Aldrich syndrome
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42768-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Generation of second messenger molecules
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Fcgamma receptor (FCGR) dependent phagocytosis
Generation of second messenger molecules
Immune System
Innate Immune System
Gene Ontology Terms (45)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (317)
1 – 10 of 317
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.999
Data Source:  Reactome,STRINGDB
WIPF1
Tbio
Novelty:  0.00427982
Score:  0.999
Data Source:  Reactome,STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
Score:  0.997
Data Source:  STRINGDB
ARPC2
Tbio
Novelty:  0.02478791
Score:  0.997
Data Source:  STRINGDB
ACTR3
Tchem
Novelty:  0.02112745
Score:  0.996
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.995
Data Source:  STRINGDB
WIPF2
Tbio
Novelty:  0.11973409
Score:  0.994
Data Source:  Reactome,STRINGDB
ARPC4
Tbio
Novelty:  0.04212335
Score:  0.993
Data Source:  STRINGDB
NCK1
Tbio
Novelty:  0.00352084
Score:  0.993
Data Source:  Reactome,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
Score:  0.993
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1206.42

PubMed score by year
PubTator Score  948.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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