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Tbio
ACAA2
3-ketoacyl-CoA thiolase, mitochondrial

Protein Summary
Description
Abolishes BNIP3-mediated apoptosis and mitochondrial damage. The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285093
  • ENSP00000285093
  • ENSG00000167315

Symbol
  • DSAEC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.98
protein domain
0.97
PubMedID
0.88
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.02   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.02   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
7
8
98.6
high density lipoprotein cholesterol measurement
11
9
15
98.2
total cholesterol measurement
1
3
3
87
Myopia
2
1
0
4.1
66.8
refractive error measurement
2
1
1
7.1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
8
98.6
high density lipoprotein cholesterol measurement
15
98.2
total cholesterol measurement
3
87
Myopia
0
4.1
66.8
refractive error measurement
1
7.1
66.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA acyltransferase 2
VGNC:5137
455414
Macaque
acetyl-CoA acyltransferase 2
709350
Mouse
MGI:1098623
52538
Rat
RGD:620482
170465
Dog
acetyl-CoA acyltransferase 2
VGNC:53324
490568
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA acyltransferase 2
Macaque
acetyl-CoA acyltransferase 2
Mouse
Rat
Dog
acetyl-CoA acyltransferase 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42765-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (150)
1 – 10 of 150
PREPL
Tchem
Family:  Enzyme
Novelty:  0.02310586
p_int:  0.795364377
p_ni:  0.204635611
p_wrong:  1.2e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
LARS2
Tbio
Family:  Enzyme
Novelty:  0.00543895
p_int:  0.791692696
p_ni:  0.208307304
Score:  0.19
Data Source:  BioPlex,STRINGDB
ACADM
Tbio
Family:  Enzyme
Novelty:  0.00548721
Score:  0.996
Data Source:  STRINGDB
HADH
Tbio
Family:  Enzyme
Novelty:  0.00368073
Score:  0.989
Data Source:  STRINGDB
HADHA
Tbio
Novelty:  0.00385746
Score:  0.985
Data Source:  STRINGDB
ACADS
Tbio
Family:  Enzyme
Novelty:  0.00841051
Score:  0.984
Data Source:  STRINGDB
ACADVL
Tbio
Family:  Enzyme
Novelty:  0.00383705
Score:  0.979
Data Source:  STRINGDB
EHHADH
Tbio
Novelty:  0.00878193
Score:  0.977
Data Source:  STRINGDB
HSD17B10
Tchem
Family:  Enzyme
Novelty:  0.00486582
Score:  0.972
Data Source:  STRINGDB
HMGCS2
Tbio
Family:  Enzyme
Novelty:  0.0103808
Score:  0.969
Data Source:  STRINGDB
Publication Statistics
PubMed Score  61.02

PubMed score by year
PubTator Score  10.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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