Tbio ACAA2 3-ketoacyl-CoA thiolase, mitochondrial

Protein Summary

Description

Abolishes BNIP3-mediated apoptosis and mitochondrial damage. The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P42765
• Q9BUT6

Gene Name

• ACAA2

Ensembl ID

• ENST00000285093
• ENSP00000285093
• ENSG00000167315

Symbol

• DSAEC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
disease perturbation	0.98
protein domain	0.97
PubMedID	0.88
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / 3-ketoacyl-coa Thiolase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / 3-ketoacyl-coa Thiolase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.41   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 317   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.41   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0