You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LRPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

Protein Summary
Description
May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260665
  • ENSP00000260665
  • ENSG00000138095

Symbol
  • LRP130
  • LSFC
  • GP130
  • LRP130
  • CLONE-23970
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
disease perturbation
0.99
kinase perturbation
0.93
hub protein
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.04   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.04   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
1
2
54.8
intelligence
1
1
0
5.5
53.2
grip strength measurement
2
2
2
51.6
self reported educational attainment
1
1
1
50.3
refractive error measurement
1
1
1
32.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
54.8
intelligence
0
5.5
53.2
grip strength measurement
2
51.6
self reported educational attainment
1
50.3
refractive error measurement
1
32.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich pentatricopeptide repeat containing
VGNC:320
459191
Macaque
leucine rich pentatricopeptide repeat containing
641443
Mouse
MGI:1919666
72416
Rat
RGD:1306575
313867
Dog
leucine rich pentatricopeptide repeat containing
VGNC:42781
474572
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich pentatricopeptide repeat containing
Macaque
leucine rich pentatricopeptide repeat containing
Mouse
Rat
Dog
leucine rich pentatricopeptide repeat containing
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P42704-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (56)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
HGNC
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (173)
1 – 10 of 173
SLIRP
Tbio
Novelty: 0.04630917
p_int: 0.999964689
p_ni: 0.000035311
Score: 0.955
Data Source: BioPlex,STRINGDB
MAP1S
Tbio
Novelty: 0.02643414
Score: 0.969
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.95
Data Source: STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.908
Data Source: STRINGDB
SOS1
Tbio
Novelty: 0.00285343
Score: 0.906
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.902
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.9
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.9
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.9
Data Source: STRINGDB
IL6R
Tclin
Novelty: 0.00185005
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.04

PubMed score by year
PubTator Score  44.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: