Tbio LIFR Leukemia inhibitory factor receptor

Protein Summary

Description

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2018]

Uniprot Accession IDs

• P42702
• Q6LCD9
• LIF receptor

Gene Name

• LIFR

Ensembl ID

• ENST00000263409
• ENSP00000263409
• ENSG00000113594
• ENST00000453190
• ENSP00000398368

Symbol

• SWS
• SJS2
• STWS
• CD118
• LIF-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
disease perturbation	0.9
virus perturbation	0.88
microRNA	0.84
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Leukemia Inhibitory Factor Receptor

Protein / Defense/immunity Protein / Leukemia Inhibitory Factor Receptor

DTO Classes

Protein / Signaling / Cytokine / Leukemia Inhibitory Factor Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.22   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 414   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.22   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0