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Tbio
LIFR
Leukemia inhibitory factor receptor

Protein Summary
Description
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263409
  • ENSP00000263409
  • ENSG00000113594
  • ENST00000453190
  • ENSP00000398368

Symbol
  • SWS
  • SJS2
  • STWS
  • CD118
  • LIF-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
disease perturbation
0.9
virus perturbation
0.88
microRNA
0.84
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.17   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.17   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene expression (Transcription)
Generic Transcription Pathway
IL-6-type cytokine receptor ligand interactions
Immune System
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (102)
1 – 10 of 102
FAM19A2
Tbio
Novelty: 0.28999346
p_int: 0.999999705
p_ni: 2.94e-7
p_wrong: 1e-9
Data Source: BioPlex
SCGB1D1
Tbio
Novelty: 0.04199997
p_int: 0.999998452
p_ni: 0.000001519
p_wrong: 2.8e-8
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.999907335
p_ni: 0.000069454
p_wrong: 0.00002321
Data Source: BioPlex
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.999894782
p_ni: 0.000077661
p_wrong: 0.000027557
Data Source: BioPlex
OS9
Tbio
Novelty: 0.01490339
p_int: 0.999320333
p_ni: 0.000322411
p_wrong: 0.000357256
Data Source: BioPlex
SLAMF1
Tbio
Novelty: 0.00112892
p_int: 0.974147935
p_ni: 0.002440756
p_wrong: 0.023411309
Data Source: BioPlex
LIF
Tbio
Novelty: 0.00094373
Score: 0.988
Data Source: Reactome,STRINGDB
CNTF
Tbio
Novelty: 0.00091188
Score: 0.985
Data Source: Reactome,STRINGDB
CNTFR
Tbio
Novelty: 0.0188716
Score: 0.982
Data Source: Reactome,STRINGDB
CTF1
Tbio
Novelty: 0.00383692
Score: 0.982
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  204.17

PubMed score by year
PubTator Score  131.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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