You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
FRK
Tyrosine-protein kinase FRK

Protein Summary
Description
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000606080
  • ENSP00000476145
  • ENSG00000111816

Symbol
  • PTK5
  • RAK
  • GTK
  • RAK
  • PTK5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.94
virus perturbation
0.76
gene perturbation
0.62
PubMedID
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.9   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 517   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.9   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (201)
PCBP1
Tbio
Novelty:  0.00906713
p_int:  1
Score:  0.521
Data Source:  BioPlex,STRINGDB
CSK
Tchem
Family:  Kinase
Novelty:  0.00186612
p_int:  0.999995858
p_ni:  0.000001175
p_wrong:  0.000002967
Score:  0.821
Data Source:  BioPlex,STRINGDB
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.956
Data Source:  Reactome,STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.934
Data Source:  STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.932
Data Source:  STRINGDB
JUP
Tbio
Novelty:  0.0081803
Score:  0.921
Data Source:  STRINGDB
PTPN6
Tchem
Family:  Enzyme
Novelty:  0.00535749
Score:  0.919
Data Source:  STRINGDB
LRRC7
Tbio
Novelty:  0.03409889
Score:  0.914
Data Source:  STRINGDB
DPP7
Tchem
Family:  Enzyme
Novelty:  0.00644738
Score:  0.913
Data Source:  STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Intracellular signaling by second messengers
Reactome
Neutrophil degranulation
Reactome
PIP3 activates AKT signaling
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Intracellular signaling by second messengers
Neutrophil degranulation
PIP3 activates AKT signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
4
4
87
serum alanine aminotransferase measurement
2
2
1
6.9
77.4
C-reactive protein measurement
2
2
2
76.6
aspartate aminotransferase measurement
2
2
1
6
75
total cholesterol measurement
4
4
4
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
87
serum alanine aminotransferase measurement
1
6.9
77.4
C-reactive protein measurement
2
76.6
aspartate aminotransferase measurement
1
6
75
total cholesterol measurement
4
74.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fyn related Src family tyrosine kinase
716267
Mouse
MGI:103265
14302
Rat
RGD:621423
79209
Dog
fyn related Src family tyrosine kinase
VGNC:40978
481970
Horse
fyn related Src family tyrosine kinase
VGNC:51030
100072625
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fyn related Src family tyrosine kinase
Mouse
Rat
Dog
fyn related Src family tyrosine kinase
Horse
fyn related Src family tyrosine kinase
Publication Statistics
PubMed Score 127.90
PubMed score by year
PubTator Score 83.94
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title