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Tchem
ABL2
Tyrosine-protein kinase ABL2

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344730
  • ENSP00000339209
  • ENSG00000143322
  • ENST00000367623
  • ENSP00000356595
  • ENST00000392043
  • ENSP00000375897
  • ENST00000502732
  • ENSP00000427562
  • ENST00000504405
  • ENSP00000426831
  • ENST00000507173
  • ENSP00000423413
  • ENST00000511413
  • ENSP00000424697
  • ENST00000512653
  • ENSP00000423578

Symbol
  • ABLL
  • ARG
  • ARG
  • ABLL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug perturbation
0.99
molecular function
0.99
protein domain
0.99
kinase perturbation
0.97


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.5   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 446   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.5   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ABL proto-oncogene 2, non-receptor tyrosine kinase
VGNC:12980
457552
Macaque
ABL proto-oncogene 2, non-receptor tyrosine kinase
717037
Mouse
MGI:87860
11352
Rat
RGD:1590898
304883
Dog
ABL proto-oncogene 2, non-receptor tyrosine kinase
VGNC:53323
480052
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ABL proto-oncogene 2, non-receptor tyrosine kinase
Macaque
ABL proto-oncogene 2, non-receptor tyrosine kinase
Mouse
Rat
Dog
ABL proto-oncogene 2, non-receptor tyrosine kinase
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42684-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (382)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Role of ABL in ROBO-SLIT signaling
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Role of ABL in ROBO-SLIT signaling
Signaling by ROBO receptors
Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (93)
1 – 10 of 93
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999998288
p_ni: 0.000001712
Score: 0.342
Data Source: BioPlex,STRINGDB
RIN1
Tbio
Novelty: 0.02401084
p_int: 0.999982327
p_ni: 0.00001767
p_wrong: 3e-9
Score: 0.929
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.999954485
p_ni: 0.000045368
p_wrong: 1.46e-7
Score: 0.294
Data Source: BioPlex,STRINGDB
HSPBP1
Tbio
Novelty: 0.01176285
p_int: 0.999951777
p_ni: 0.000013179
p_wrong: 0.000035045
Score: 0.396
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.9999404
p_ni: 0.000059586
p_wrong: 1.3e-8
Score: 0.915
Data Source: BioPlex,STRINGDB
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.999586506
p_ni: 0.00036636
p_wrong: 0.000047134
Score: 0.961
Data Source: BioPlex,STRINGDB
BAG5
Tbio
Novelty: 0.0318404
p_int: 0.999333008
p_ni: 0.00053023
p_wrong: 0.000136763
Score: 0.538
Data Source: BioPlex,STRINGDB
CRK
Tbio
Novelty: 0.00238512
Score: 0.979
Data Source: STRINGDB
CRKL
Tbio
Novelty: 0.0051181
Score: 0.959
Data Source: STRINGDB
PSMA7
Tbio
Family: Enzyme
Novelty: 0.01385043
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  94.50

PubMed score by year
PubTator Score  45.67

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer