Tchem ABL2 Tyrosine-protein kinase ABL2

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Abl Family / Abelson Tyrosine-protein Kinase 2

Protein Summary

Description

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• P42684
• A0M8X0
• B7UEF2
• B7UEF3
• B7UEF4
• B7UEF5
• Q5T0X6
• Q5W0C5
• Q6NZY6
• Q7Z301

Gene Name

• ABL2

Ensembl ID

• ENST00000344730
• ENSP00000339209
• ENSG00000143322
• ENST00000367623
• ENSP00000356595
• ENST00000392043
• ENSP00000375897
• ENST00000502732
• ENSP00000427562
• ENST00000504405
• ENSP00000426831
• ENST00000507173
• ENSP00000423413
• ENST00000511413
• ENSP00000424697
• ENST00000512653
• ENSP00000423578

Symbol

• ABLL
• ARG
• ARG
• ABLL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
drug perturbation	0.99
molecular function	0.99
protein domain	0.99
kinase perturbation	0.97

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.69   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 446   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.69   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4

Approved Drugs (4)

Explore Approved Drugs

1 – 4 of 4

dasatinib

ABL2Tchem Kinase

Kd: 9.77

bosutinib

ABL2Tchem Kinase

Kd: 8.82

imatinib

ABL2Tchem Kinase

Kd: 8.22

nilotinib

ABL2Tchem Kinase

Kd: 7.59

Active Ligands (13)

Explore Active Ligands

1 – 10 of 13

CHEMBL1230609

ABL2Tchem Kinase

Kd: 7.57

CHEMBL574738

ABL2Tchem Kinase

Kd: 8.47

CHEMBL572878

ABL2Tchem Kinase

Kd: 8.4

CHEMBL386051

ABL2Tchem Kinase

Kd: 9.16

pexmetinib

ABL2Tchem Kinase

IC50: 8

CHEMBL2324924

ABL2Tchem Kinase

IC50: 9

CHEMBL2324926

ABL2Tchem Kinase

IC50: 8.22

CHEMBL2324925

ABL2Tchem Kinase

IC50: 8.52

CHEMBL2324923

ABL2Tchem Kinase

IC50: 7.96

CHEMBL2324931

ABL2Tchem Kinase

IC50: 7.75

Protein Data Bank (9)

1 – 5 of 9

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (382)

Reactome (4)

KEGG (3)

PathwayCommons (1)

WikiPathways (374)

Axon guidance (R-HSA-422475)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Role of ABL in ROBO-SLIT signaling	8 targets	R-HSA-428890
Reactome	Signaling by ROBO receptors	220 targets	R-HSA-376176

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
Role of ABL in ROBO-SLIT signaling	8 targets	R-HSA-428890
Signaling by ROBO receptors	220 targets	R-HSA-376176

Gene Ontology Terms (28)

Functions (9)

Components (2)

Processes (17)

Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
magnesium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
manganese ion binding	Inferred from Direct Assay (IDA)	UniProtKB
protein tyrosine kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
phosphotyrosine residue binding	Inferred from Physical Interaction (IPI)	CAFA
non-membrane spanning protein tyrosine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
actin filament binding	Traceable Author Statement (TAS)	UniProtKB
actin monomer binding	Traceable Author Statement (TAS)	UniProtKB
protein kinase activity	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (93)

Explore Interacting Targets

1 – 10 of 93

• See Interactions on String-DB

NCK2

Tbio

Novelty: 0.02908657

p_int: 0.999998288

p_ni: 0.000001712

Score: 0.342

Data Source: BioPlex,STRINGDB

RIN1

Tbio

Novelty: 0.02228321

p_int: 0.999982327

p_ni: 0.00001767

p_wrong: 3e-9

Score: 0.929

Data Source: BioPlex,STRINGDB

HSPA8

Tchem

Novelty: 0.00100906

p_int: 0.999954485

p_ni: 0.000045368

p_wrong: 1.46e-7

Score: 0.294

Data Source: BioPlex,STRINGDB

HSPBP1

Tbio

Novelty: 0.01599246

p_int: 0.999951777

p_ni: 0.000013179

p_wrong: 0.000035045

Score: 0.396

Data Source: BioPlex,STRINGDB

ABI2

Tbio

Novelty: 0.03279246

p_int: 0.9999404

p_ni: 0.000059586

p_wrong: 1.3e-8

Score: 0.915

Data Source: BioPlex,STRINGDB

NCK1

Tbio

Novelty: 0.00554007

p_int: 0.999586506

p_ni: 0.00036636

p_wrong: 0.000047134

Score: 0.961

Data Source: BioPlex,STRINGDB

BAG5

Tbio

Novelty: 0.05540868

p_int: 0.999333008

p_ni: 0.00053023

p_wrong: 0.000136763

Score: 0.538

Data Source: BioPlex,STRINGDB

CRK

Tbio

Novelty: 0.00270563

Score: 0.979

Data Source: STRINGDB

CRKL

Tbio

Novelty: 0.0061856

Score: 0.959

Data Source: STRINGDB

PSMA7

Tbio

Family: Enzyme

Novelty: 0.00166058

Score: 0.958

Data Source: STRINGDB

Publication Statistics

PubMed Score  81.69

PubMed score by year

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PubTator Score  45.67

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGG

1-70

SSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN

70-140

QNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSIS

140-210

LRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK

210-280

WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGV

280-350

CTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN

350-420

HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID

420-490

LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAA

490-560

SSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDK

560-630

SPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADG

630-700

FSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTA

700-770

SDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES

770-840

AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQ

840-910

PGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKP

910-980

KCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPT

980-1050

SSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYC

1050-1120

SGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR

1120-1182

MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR

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Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
ATP-binding
Cell adhesion
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Lipoprotein