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Tchem
ABL2
Tyrosine-protein kinase ABL2

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344730
  • ENSP00000339209
  • ENSG00000143322
  • ENST00000367623
  • ENSP00000356595
  • ENST00000392043
  • ENSP00000375897
  • ENST00000502732
  • ENSP00000427562
  • ENST00000504405
  • ENSP00000426831
  • ENST00000507173
  • ENSP00000423413
  • ENST00000511413
  • ENSP00000424697
  • ENST00000512653
  • ENSP00000423578

Symbol
  • ABLL
  • ARG
  • ARG
  • ABLL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug perturbation
0.99
molecular function
0.99
protein domain
0.99
kinase perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.69   (req: < 5)
View Publications
Gene RIFs: 28   (req: <= 3)
View Gene RIFs
Antibodies: 446   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.69   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Explore Approved Drugs
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (382)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
533 targets
R-HSA-422475
Reactome
Developmental Biology
1055 targets
R-HSA-1266738
Reactome
Role of ABL in ROBO-SLIT signaling
8 targets
R-HSA-428890
Reactome
Signaling by ROBO receptors
220 targets
R-HSA-376176
Name
Explore in Pharos
Explore in Source
Axon guidance
533 targets
R-HSA-422475
Developmental Biology
1055 targets
R-HSA-1266738
Role of ABL in ROBO-SLIT signaling
8 targets
R-HSA-428890
Signaling by ROBO receptors
220 targets
R-HSA-376176
Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
magnesium ion binding
Inferred from Direct Assay (IDA)
UniProtKB
manganese ion binding
Inferred from Direct Assay (IDA)
UniProtKB
protein tyrosine kinase activity
Inferred from Direct Assay (IDA)
UniProtKB
phosphotyrosine residue binding
Inferred from Physical Interaction (IPI)
CAFA
non-membrane spanning protein tyrosine kinase activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
actin filament binding
Traceable Author Statement (TAS)
UniProtKB
actin monomer binding
Traceable Author Statement (TAS)
UniProtKB
protein kinase activity
Traceable Author Statement (TAS)
ProtInc
ATP binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (93)
1 – 10 of 93
NCK2
Tbio
Novelty: 0.02908657
p_int: 0.999998288
p_ni: 0.000001712
Score: 0.342
Data Source: BioPlex,STRINGDB
RIN1
Tbio
Novelty: 0.02228321
p_int: 0.999982327
p_ni: 0.00001767
p_wrong: 3e-9
Score: 0.929
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00100906
p_int: 0.999954485
p_ni: 0.000045368
p_wrong: 1.46e-7
Score: 0.294
Data Source: BioPlex,STRINGDB
HSPBP1
Tbio
Novelty: 0.01599246
p_int: 0.999951777
p_ni: 0.000013179
p_wrong: 0.000035045
Score: 0.396
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.03279246
p_int: 0.9999404
p_ni: 0.000059586
p_wrong: 1.3e-8
Score: 0.915
Data Source: BioPlex,STRINGDB
NCK1
Tbio
Novelty: 0.00554007
p_int: 0.999586506
p_ni: 0.00036636
p_wrong: 0.000047134
Score: 0.961
Data Source: BioPlex,STRINGDB
BAG5
Tbio
Novelty: 0.05540868
p_int: 0.999333008
p_ni: 0.00053023
p_wrong: 0.000136763
Score: 0.538
Data Source: BioPlex,STRINGDB
CRK
Tbio
Novelty: 0.00270563
Score: 0.979
Data Source: STRINGDB
CRKL
Tbio
Novelty: 0.0061856
Score: 0.959
Data Source: STRINGDB
PSMA7
Tbio
Family: Enzyme
Novelty: 0.00166058
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  81.69

PubMed score by year
PubTator Score  45.67

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer