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Tchem
TEC
Tyrosine-protein kinase Tec

Protein Summary
Description
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381501
  • ENSP00000370912
  • ENSG00000135605

Symbol
  • PSCTK4
  • PSCTK4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
interacting protein
0.93
histone modification site profile
0.89
hub protein
0.85


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.1   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.1   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
28.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
28.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tec protein tyrosine kinase
VGNC:732
461343
Macaque
tec protein tyrosine kinase
705357
Mouse
MGI:98662
21682
Rat
RGD:620973
84492
Dog
tec protein tyrosine kinase
VGNC:47231
482140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tec protein tyrosine kinase
Macaque
tec protein tyrosine kinase
Mouse
Rat
Dog
tec protein tyrosine kinase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42680-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FCERI mediated Ca+2 mobilization
Reactome
Fc epsilon receptor (FCERI) signaling
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FCERI mediated Ca+2 mobilization
Fc epsilon receptor (FCERI) signaling
Immune System
Innate Immune System
Protein-Protein Interactions (46)
1 – 10 of 46
DOK1
Tbio
Novelty: 0.01976327
Score: 0.963
Data Source: STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.961
Data Source: Reactome,STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.959
Data Source: Reactome,STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00294726
Score: 0.956
Data Source: Reactome,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.95
Data Source: Reactome,STRINGDB
VAV3
Tbio
Novelty: 0.010944
Score: 0.942
Data Source: Reactome,STRINGDB
VAV2
Tbio
Novelty: 0.01062502
Score: 0.942
Data Source: Reactome,STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.941
Data Source: STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.94
Data Source: Reactome,STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.939
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  7.10

PubMed score by year
PubTator Score  71.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer