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Tbio
MATK
Megakaryocyte-associated tyrosine-protein kinase

Protein Summary
Description
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Thr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310132
  • ENSP00000308734
  • ENSG00000007264
  • ENST00000395040
  • ENSP00000378481
  • ENST00000395045
  • ENSP00000378485
  • ENST00000619596
  • ENSP00000483213

Symbol
  • CTK
  • HYL
  • CHK
  • CTK
  • HYL
  • Lsk
  • HYLTK
  • HHYLTK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.94
small molecule perturbation
0.65
disease perturbation
0.56
disease
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1553.03   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1553.03   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
energy expenditure
1
1
1
11.8
insulin sensitivity measurement
1
1
1
11.8
hip circumference
1
1
1
11.8
C-reactive protein measurement
1
1
1
11.8
testosterone measurement
1
1
1
11.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
energy expenditure
1
11.8
insulin sensitivity measurement
1
11.8
hip circumference
1
11.8
C-reactive protein measurement
1
11.8
testosterone measurement
1
11.8
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Downregulation of ERBB2 signaling (R-HSA-8863795)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of ERBB2 signaling
Reactome
Signal Transduction
Reactome
Signaling by ERBB2
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Downregulation of ERBB2 signaling
Signal Transduction
Signaling by ERBB2
Signaling by Receptor Tyrosine Kinases
Protein-Protein Interactions (117)
1 – 10 of 117
CSK
Tchem
Family: Kinase
Novelty: 0.00186612
p_int: 0.999999942
p_wrong: 5.8e-8
Score: 0.687
Data Source: BioPlex,STRINGDB
KITLG
Tbio
Novelty: 0.00036337
Score: 0.957
Data Source: STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.956
Data Source: STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.943
Data Source: Reactome,STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.935
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.921
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.917
Data Source: STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.916
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.913
Data Source: Reactome,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.909
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1553.03

PubMed score by year
PubTator Score  526.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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