Tbio DPP6 Dipeptidyl aminopeptidase-like protein 6

Protein Summary

Description

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• P42658

Gene Name

• DPP6

Ensembl ID

• ENST00000332007
• ENSP00000328226
• ENSG00000130226
• ENST00000377770
• ENSP00000367001
• ENST00000634466
• ENSP00000488956
• ENSG00000282974
• ENST00000634541
• ENSP00000489137

Symbol

• VF2
• DPL1
• DPPX
• MRD33

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
transcription factor	0.74
PubMedID	0.66
disease	0.62
tissue	0.62

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Dipeptidyl Aminopeptidase-like Protein 6

Protein / Enzyme Modulator / Dipeptidyl Aminopeptidase-like Protein 6

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Dipeptidyl Aminopeptidase-like Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.58   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.58   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0