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Tbio
DPP6
Dipeptidyl aminopeptidase-like protein 6

Protein Summary
Description
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332007
  • ENSP00000328226
  • ENSG00000130226
  • ENST00000377770
  • ENSP00000367001
  • ENST00000634466
  • ENSP00000488956
  • ENSG00000282974
  • ENST00000634541
  • ENSP00000489137

Symbol
  • VF2
  • DPL1
  • DPPX
  • MRD33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor
0.74
PubMedID
0.66
disease
0.62
tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.19   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.19   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
1
1
0
8
53.3
refractive error measurement
1
1
0
8
53.3
age at onset
1
1
0
8
53.3
1
1
0
1.3
45.5
gut microbiome measurement
1
1
0
2.3
40.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
0
8
53.3
refractive error measurement
0
8
53.3
age at onset
0
8
53.3
0
1.3
45.5
gut microbiome measurement
0
2.3
40.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase like 6
VGNC:14005
463835
Macaque
dipeptidyl peptidase like 6
718148
Mouse
MGI:94921
13483
Rat
RGD:68402
29272
Dog
dipeptidyl peptidase like 6
VGNC:40075
475553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase like 6
Macaque
dipeptidyl peptidase like 6
Mouse
Rat
Dog
dipeptidyl peptidase like 6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42658-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (115)
1 – 10 of 115
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999787652
p_ni: 7.87e-7
p_wrong: 0.000211561
Score: 0.165
Data Source: BioPlex,STRINGDB
CSGALNACT2
Tbio
Family: Enzyme
Novelty: 0.0770692
p_int: 0.999631913
p_ni: 0.000368085
p_wrong: 2e-9
Data Source: BioPlex
APOL2
Tbio
Novelty: 0.06076255
p_int: 0.983802268
p_ni: 0.01583508
p_wrong: 0.000362652
Data Source: BioPlex
ATP5MC1
Tbio
Family: Enzyme
Novelty: 0.03538978
p_int: 0.954127157
p_ni: 0.045695151
p_wrong: 0.000177692
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.929515254
p_ni: 0.000020319
p_wrong: 0.070464426
Data Source: BioPlex
NUDT9
Tbio
Family: Enzyme
Novelty: 0.0482661
p_int: 0.908112537
p_ni: 0.045411192
p_wrong: 0.046476271
Data Source: BioPlex
UXS1
Tbio
Family: Enzyme
Novelty: 0.04671281
p_int: 0.896870928
p_ni: 0.080329294
p_wrong: 0.022799777
Data Source: BioPlex
POMGNT2
Tbio
Family: Enzyme
Novelty: 0.15109569
p_int: 0.848550223
p_ni: 0.151449777
Data Source: BioPlex
LAMB1
Tbio
Novelty: 0.0104285
p_int: 0.757696024
p_ni: 0.242303976
Data Source: BioPlex
TNFSF9
Tbio
Novelty: 0.00532152
p_int: 0.755510167
p_ni: 0.244486593
p_wrong: 0.00000324
Data Source: BioPlex
Publication Statistics
PubMed Score  226.19

PubMed score by year
PubTator Score  86.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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