Protein Classes
Protein Summary
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 20 ...more
- ENST00000310447
- ENSP00000312664
- ENSG00000106144
- ICH1
- NEDD2
- ICH1
- NEDD2
- CASP-2
- NEDD-2
- PPP1R57
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
disease perturbation | 0.97 | ||
kinase perturbation | 0.91 | ||
biological process | 0.9 | ||
chemical | 0.9 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 462.34 (req: < 5)
Gene RIFs: 96 (req: <= 3)
Antibodies: 746 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 462.34 (req: >= 5)
Gene RIFs: 96 (req: > 3)
Antibodies: 746 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 27
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (27)
1 – 10 of 27
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (84)
Reactome (15)
KEGG (1)
PathwayCommons (5)
WikiPathways (63)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell death signalling via NRAGE, NRIF and NADE | ||||
Death Receptor Signalling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Gene Ontology Terms (29)
Functions (6)
Components (5)
Processes (18)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (162)
1 – 10 of 162
BBOX1
Family: Enzyme
Novelty: 0.00263045
p_int: 0.999998359
p_ni: 2e-9
p_wrong: 0.000001639
Score: 0.237
Data Source: BioPlex,STRINGDB
HNRNPK
Novelty: 0.00343899
p_int: 0.999993852
p_ni: 3.01e-7
p_wrong: 0.000005848
Score: 0.38
Data Source: BioPlex,STRINGDB
EPN3
Novelty: 0.14281801
p_int: 0.999952275
p_ni: 0.000039001
p_wrong: 0.000008724
Score: 0.303
Data Source: BioPlex,STRINGDB
CRADD
Novelty: 0.03789025
Score: 0.999
Data Source: Reactome,STRINGDB
BID
Novelty: 0.01362871
Score: 0.999
Data Source: STRINGDB
BCL2L1
Novelty: 0.00021916
Score: 0.997
Data Source: STRINGDB
XIAP
Family: Enzyme
Novelty: 0.00068225
Score: 0.997
Data Source: STRINGDB
BCL2
Novelty: 0.00566111
Score: 0.995
Data Source: STRINGDB
CASP8
Family: Enzyme
Novelty: 0.00026844
Score: 0.995
Data Source: STRINGDB
CASP9
Family: Enzyme
Novelty: 0.00031573
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score 462.34
PubMed score by year
PubTator Score 438.7
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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