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Tchem
CASP2
Caspase-2

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 20 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310447
  • ENSP00000312664
  • ENSG00000106144

Symbol
  • ICH1
  • NEDD2
  • ICH1
  • NEDD2
  • CASP-2
  • NEDD-2
  • PPP1R57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease perturbation
0.97
kinase perturbation
0.91
biological process
0.9
chemical
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.34   (req: < 5)
View Publications
Gene RIFs: 96   (req: <= 3)
View Gene RIFs
Antibodies: 746   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.34   (req: >= 5)
Gene RIFs: 96   (req: > 3)
Antibodies: 746   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (84)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
76 targets
R-HSA-204998
Reactome
Death Receptor Signalling
141 targets
R-HSA-73887
Reactome
Gene expression (Transcription)
1452 targets
R-HSA-74160
Reactome
Generic Transcription Pathway
1195 targets
R-HSA-212436
Reactome
Immune System
2246 targets
R-HSA-168256
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
76 targets
R-HSA-204998
Death Receptor Signalling
141 targets
R-HSA-73887
Gene expression (Transcription)
1452 targets
R-HSA-74160
Generic Transcription Pathway
1195 targets
R-HSA-212436
Immune System
2246 targets
R-HSA-168256
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
cysteine-type endopeptidase activity
Inferred from Direct Assay (IDA)
UniProtKB
identical protein binding
Inferred from Physical Interaction (IPI)
IntAct
protein domain specific binding
Inferred from Physical Interaction (IPI)
BHF-UCL
cysteine-type endopeptidase activity involved in apoptotic process
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
enzyme binding
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
cysteine-type endopeptidase activity involved in execution phase of apoptosis
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (162)
1 – 10 of 162
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00263045
p_int: 0.999998359
p_ni: 2e-9
p_wrong: 0.000001639
Score: 0.237
Data Source: BioPlex,STRINGDB
HNRNPK
Tbio
Novelty: 0.00343899
p_int: 0.999993852
p_ni: 3.01e-7
p_wrong: 0.000005848
Score: 0.38
Data Source: BioPlex,STRINGDB
EPN3
Tbio
Novelty: 0.14281801
p_int: 0.999952275
p_ni: 0.000039001
p_wrong: 0.000008724
Score: 0.303
Data Source: BioPlex,STRINGDB
CRADD
Tbio
Novelty: 0.03789025
Score: 0.999
Data Source: Reactome,STRINGDB
BID
Tbio
Novelty: 0.01362871
Score: 0.999
Data Source: STRINGDB
BCL2L1
Tchem
Novelty: 0.00021916
Score: 0.997
Data Source: STRINGDB
XIAP
Tchem
Family: Enzyme
Novelty: 0.00068225
Score: 0.997
Data Source: STRINGDB
BCL2
Tclin
Novelty: 0.00566111
Score: 0.995
Data Source: STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00026844
Score: 0.995
Data Source: STRINGDB
CASP9
Tchem
Family: Enzyme
Novelty: 0.00031573
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  462.34

PubMed score by year
PubTator Score  438.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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