Tchem CASP2 Caspase-2

Protein Summary

Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• P42575
• A8K5F9
• D3DXD6
• E9PDN0
• P42576
• Q59F21
• Q7KZL6
• Q86UJ3
• Q9BUP7
• Q9BZK9
• Q9BZL0
• CASP-2

Gene Name

• CASP2

Ensembl ID

• ENST00000310447
• ENSP00000312664
• ENSG00000106144

Symbol

• ICH1
• NEDD2
• ICH1
• NEDD2
• CASP-2
• NEDD-2
• PPP1R57

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
disease perturbation	0.97
kinase perturbation	0.91
biological process	0.9
chemical	0.9

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Caspase-2

Protein / Enzyme Modulator / Protease Inhibitor / Caspase-2

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Caspase-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.08   (req: < 5)

Gene RIFs: 115   (req: <= 3)

Antibodies: 746   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.08   (req: >= 5)

Gene RIFs: 115   (req: > 3)

Antibodies: 746   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0