Tchem CASP2 Caspase-2

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Caspase-2

Protein / Enzyme Modulator / Protease Inhibitor / Caspase-2

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Caspase-2

Protein Summary

Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• P42575
• A8K5F9
• D3DXD6
• E9PDN0
• P42576
• Q59F21
• Q7KZL6
• Q86UJ3
• Q9BUP7
• Q9BZK9
• Q9BZL0
• CASP-2

Gene Name

• CASP2

Ensembl ID

• ENST00000310447
• ENSP00000312664
• ENSG00000106144

Symbol

• ICH1
• NEDD2
• ICH1
• NEDD2
• CASP-2
• NEDD-2
• PPP1R57

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
disease perturbation	0.97
kinase perturbation	0.91
biological process	0.9
chemical	0.9

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.49   (req: < 5)

Gene RIFs: 96   (req: <= 3)

Antibodies: 746   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.49   (req: >= 5)

Gene RIFs: 96   (req: > 3)

Antibodies: 746   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (27)

Explore Active Ligands

1 – 10 of 27

CHEMBL203709

CASP2Tchem Enzyme

IC50 : 6.27

CHEMBL382481

CASP2Tchem Enzyme

IC50 : 6.28

CHEMBL439872

CASP2Tchem Enzyme

IC50 : 6.63

CHEMBL438969

CASP2Tchem Enzyme

IC50 : 6.64

CHEMBL358725

CASP2Tchem Enzyme

Ki : 6.02

CHEMBL202971

CASP2Tchem Enzyme

IC50 : 6.07

CHEMBL147763

CASP2Tchem Enzyme

Ki : 6.01999998

CHEMBL1835211

CASP2Tchem Enzyme

IC50 : 6.97

CHEMBL1835403

CASP2Tchem Enzyme

IC50 : 6.79

CHEMBL1835208

CASP2Tchem Enzyme

IC50 : 7.39

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	caspase 2	VGNC:4294	463804
Mouse	caspase 2	MGI:97295	12366
Rat	caspase 2	RGD:69274	64314
Dog	caspase 2	VGNC:38733	482737
Horse	caspase 2	VGNC:16067	100050611

Species	Name	OMA	EggNOG	Inparanoid
Chimp	caspase 2
Mouse	caspase 2
Rat	caspase 2
Dog	caspase 2
Horse	caspase 2

Protein Structure (9 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42575-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (84)

Reactome (15)

KEGG (1)

PathwayCommons (5)

WikiPathways (63)

Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

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Items per page:

5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Reactome	Death Receptor Signalling	141 targets	R-HSA-73887
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Death Receptor Signalling	141 targets	R-HSA-73887
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (29)

Functions (6)

Components (5)

Processes (18)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
cysteine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein domain specific binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cysteine-type endopeptidase activity involved in apoptotic process	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
enzyme binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
cysteine-type endopeptidase activity involved in execution phase of apoptosis	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (162)

Explore Interacting Targets

1 – 10 of 162

• See Interactions on String-DB

BBOX1

Tchem

Family: Enzyme

Novelty: 0.00255489

p_int: 0.999998359

p_ni: 2e-9

p_wrong: 0.000001639

Score: 0.237

Data Source: BioPlex,STRINGDB

HNRNPK

Tbio

Novelty: 0.00354731

p_int: 0.999993852

p_ni: 3.01e-7

p_wrong: 0.000005848

Score: 0.38

Data Source: BioPlex,STRINGDB

EPN3

Tbio

Novelty: 0.12685855

p_int: 0.999952275

p_ni: 0.000039001

p_wrong: 0.000008724

Score: 0.303

Data Source: BioPlex,STRINGDB

CRADD

Tbio

Novelty: 0.02761299

Score: 0.999

Data Source: Reactome,STRINGDB

BID

Tbio

Novelty: 0.01264688

Score: 0.999

Data Source: STRINGDB

BCL2L1

Tchem

Novelty: 0.00018414

Score: 0.997

Data Source: STRINGDB

XIAP

Tchem

Family: Enzyme

Novelty: 0.00062268

Score: 0.997

Data Source: STRINGDB

BCL2

Tclin

Novelty: 0.00608635

Score: 0.995

Data Source: STRINGDB

CASP8

Tchem

Family: Enzyme

Novelty: 0.00024321

Score: 0.995

Data Source: STRINGDB

CASP9

Tchem

Family: Enzyme

Novelty: 0.00023687

Score: 0.994

Data Source: STRINGDB

Publication Statistics

PubMed Score  541.49

PubMed score by year

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PubTator Score  438.7

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Apoptosis
Complete proteome
Hydrolase
Phosphoprotein
Polymorphism
Protease
Reference proteome

MGI Phenotype Find Similar Targets

cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
nervous system phenotype
reproductive system phenotype