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Tchem
CASP2
Caspase-2

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 20 ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease perturbation
0.97
kinase perturbation
0.91
biological process
0.9
chemical
0.9


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.49   (req: < 5)
Gene RIFs: 96   (req: <= 3)
Antibodies: 746   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.49   (req: >= 5)
Gene RIFs: 96   (req: > 3)
Antibodies: 746   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase 2
VGNC:4294
463804
Mouse
MGI:97295
12366
Rat
RGD:69274
64314
Dog
caspase 2
VGNC:38733
482737
Horse
caspase 2
VGNC:16067
100050611
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase 2
Mouse
Rat
Dog
caspase 2
Horse
caspase 2
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42575-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (84)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (162)
1 – 10 of 162
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00255489
p_int: 0.999998359
p_ni: 2e-9
p_wrong: 0.000001639
Score: 0.237
Data Source: BioPlex,STRINGDB
HNRNPK
Tbio
Novelty: 0.00354731
p_int: 0.999993852
p_ni: 3.01e-7
p_wrong: 0.000005848
Score: 0.38
Data Source: BioPlex,STRINGDB
EPN3
Tbio
Novelty: 0.12685855
p_int: 0.999952275
p_ni: 0.000039001
p_wrong: 0.000008724
Score: 0.303
Data Source: BioPlex,STRINGDB
CRADD
Tbio
Novelty: 0.02761299
Score: 0.999
Data Source: Reactome,STRINGDB
BID
Tbio
Novelty: 0.01264688
Score: 0.999
Data Source: STRINGDB
BCL2L1
Tchem
Novelty: 0.00018414
Score: 0.997
Data Source: STRINGDB
XIAP
Tchem
Family: Enzyme
Novelty: 0.00062268
Score: 0.997
Data Source: STRINGDB
BCL2
Tclin
Novelty: 0.00608635
Score: 0.995
Data Source: STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
Score: 0.995
Data Source: STRINGDB
CASP9
Tchem
Family: Enzyme
Novelty: 0.00023687
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  541.49

PubMed score by year
PubTator Score  438.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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