Pharos : Target Details

Tchem

Protein Classes

Protein Summary

Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 20 ...more

Uniprot Accession IDs

Gene Name

CASP2

Ensembl ID

ENST00000310447
ENSP00000312664
ENSG00000106144

Symbol

ICH1
NEDD2
ICH1
NEDD2
CASP-2
NEDD-2
PPP1R57

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99

disease perturbation	0.97

kinase perturbation	0.91

biological process	0.9

chemical	0.9

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 549.58 (req: < 5)

View Publications

Gene RIFs: 96 (req: <= 3)

View Gene RIFs

Antibodies: 746 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 549.58 (req: >= 5)

Gene RIFs: 96 (req: > 3)

Antibodies: 746 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (26)

1 – 10 of 26

GWAS Traits (6)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
serum gamma-glutamyl transferase measurement	EFO_0004532	2	2	2	89.2

basophil count	EFO_0005090	3	1	3	85.2

basophil percentage of leukocytes	EFO_0007992	1	1	1	84.9

monocyte count	EFO_0005091	1	1	1	74.8

sex hormone-binding globulin measurement	EFO_0004696	4	1	4	64.4

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
serum gamma-glutamyl transferase measurement	EFO_0004532	2	89.2

basophil count	EFO_0005090	3	85.2

basophil percentage of leukocytes	EFO_0007992	1	84.9

monocyte count	EFO_0005091	1	74.8

sex hormone-binding globulin measurement	EFO_0004696	4	64.4

Beta Count

Odds Ratio

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID
Chimp	caspase 2	VGNC:4294	463804

Mouse	caspase 2	MGI:97295	12366

Rat	caspase 2	RGD:69274	64314

Dog	caspase 2	VGNC:38733	482737

Horse	caspase 2	VGNC:16067	100050611

Species	Name	OMA	EggNOG	Inparanoid
Chimp	caspase 2

Mouse	caspase 2

Rat	caspase 2

Dog	caspase 2

Horse	caspase 2

Protein Structure (9 Structures, 1 AlphaFold Model)

1 – 5 of 9

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (84)

Reactome (15)

KEGG (1)

PathwayCommons (5)

WikiPathways (63)

Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

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Items per page:

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998

Reactome	Death Receptor Signalling	141 targets	R-HSA-73887

Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160

Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998

Death Receptor Signalling	141 targets	R-HSA-73887

Gene expression (Transcription)	1452 targets	R-HSA-74160

Generic Transcription Pathway	1195 targets	R-HSA-212436

Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (29)

Functions (6)

Components (5)

Processes (18)

Items per page:

1 – 6 of 6

GO Term	Evidence	Assigned by
cysteine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB

identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

protein domain specific binding	Inferred from Physical Interaction (IPI)	BHF-UCL

cysteine-type endopeptidase activity involved in apoptotic process	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

enzyme binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

cysteine-type endopeptidase activity involved in execution phase of apoptosis	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (162)

1 – 10 of 162

See Interactions on String-DB

BBOX1

Tchem

Family: Enzyme

Novelty: 0.00255489

p_int: 0.999998359

p_ni: 2e-9

p_wrong: 0.000001639

Score: 0.237

Data Source: BioPlex,STRINGDB

HNRNPK

Tbio

Novelty: 0.00354731

p_int: 0.999993852

p_ni: 3.01e-7

p_wrong: 0.000005848

Score: 0.38

Data Source: BioPlex,STRINGDB

EPN3

Tbio

Novelty: 0.12685855

p_int: 0.999952275

p_ni: 0.000039001

p_wrong: 0.000008724

Score: 0.303

Data Source: BioPlex,STRINGDB

CRADD

Tbio

Novelty: 0.02761299

Score: 0.999

Data Source: Reactome,STRINGDB

BID

Tbio

Novelty: 0.01264688

Score: 0.999

Data Source: STRINGDB

BCL2L1

Tchem

Novelty: 0.00018414

Score: 0.997

Data Source: STRINGDB

XIAP

Tchem

Family: Enzyme

Novelty: 0.00062268

Score: 0.997

Data Source: STRINGDB

BCL2

Tclin

Novelty: 0.00608635

Score: 0.995

Data Source: STRINGDB

CASP8

Tchem

Family: Enzyme

Novelty: 0.00024321

Score: 0.995

Data Source: STRINGDB

CASP9

Tchem

Family: Enzyme

Novelty: 0.00023687

Score: 0.994

Data Source: STRINGDB

Publication Statistics

PubMed Score 549.58

PubMed score by year

PubTator Score 438.7

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword

No Header	No Header
3D-structure

Acetylation

Alternative splicing

Apoptosis

Complete proteome

Hydrolase

Phosphoprotein

Polymorphism

Protease

Reference proteome

GWAS Trait

No Header	No Header
basophil count

basophil percentage of leukocytes

monocyte count

monocyte percentage of leukocytes

serum gamma-glutamyl transferase measurement

sex hormone-binding globulin measurement

MGI Phenotype

No Header	No Header
cellular phenotype

endocrine/exocrine gland phenotype

hematopoietic system phenotype

immune system phenotype

nervous system phenotype

reproductive system phenotype