Protein Summary
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 20 ...more
- ENST00000310447
- ENSP00000312664
- ENSG00000106144
- ICH1
- NEDD2
- ICH1
- NEDD2
- CASP-2
- NEDD-2
- PPP1R57
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
disease perturbation | 0.97 | ||
kinase perturbation | 0.91 | ||
biological process | 0.9 | ||
chemical | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 549.58 (req: < 5)
Gene RIFs: 96 (req: <= 3)
Antibodies: 746 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 549.58 (req: >= 5)
Gene RIFs: 96 (req: > 3)
Antibodies: 746 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 26
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (26)
Protein-Protein Interactions (162)
BBOX1
Family: Enzyme
Novelty: 0.00255489
p_int: 0.999998359
p_ni: 2e-9
p_wrong: 0.000001639
Score: 0.237
Data Source: BioPlex,STRINGDB
HNRNPK
Novelty: 0.00354731
p_int: 0.999993852
p_ni: 3.01e-7
p_wrong: 0.000005848
Score: 0.38
Data Source: BioPlex,STRINGDB
EPN3
Novelty: 0.12685855
p_int: 0.999952275
p_ni: 0.000039001
p_wrong: 0.000008724
Score: 0.303
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (84)
Reactome (15)
KEGG (1)
PathwayCommons (5)
WikiPathways (63)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell death signalling via NRAGE, NRIF and NADE | ||||
Death Receptor Signalling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (6)
Components (5)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 89.2 | |||||
basophil count | 3 | 1 | 3 | 85.2 | |||||
basophil percentage of leukocytes | 1 | 1 | 1 | 84.9 | |||||
monocyte count | 1 | 1 | 1 | 74.8 | |||||
sex hormone-binding globulin measurement | 4 | 1 | 4 | 64.4 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 89.2 | |||||
basophil count | 3 | 85.2 | |||||
basophil percentage of leukocytes | 1 | 84.9 | |||||
monocyte count | 1 | 74.8 | |||||
sex hormone-binding globulin measurement | 4 | 64.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | caspase 2 | VGNC:4294 | 463804 | |||||
Mouse | MGI:97295 | 12366 | ||||||
Rat | RGD:69274 | 64314 | ||||||
Dog | caspase 2 | VGNC:38733 | 482737 | |||||
Horse | caspase 2 | VGNC:16067 | 100050611 | |||||
Publication Statistics
PubMed Score 549.58
PubMed score by year
PubTator Score 438.70
PubTator score by year
Related Publications
Text Mined References (149)
GeneRif Annotations (96)
Items per page:
0 of 0
PMID | Year | Title |
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