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Tchem
CASP3
Caspase-3

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308394
  • ENSP00000311032
  • ENSG00000164305
  • ENST00000523916
  • ENSP00000428929

Symbol
  • CPP32
  • CPP32
  • SCA-1
  • CPP32B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
protein domain
0.92
pathway
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27214.16   (req: < 5)
Gene RIFs: 716   (req: <= 3)
Antibodies: 2221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27214.16   (req: >= 5)
Gene RIFs: 716   (req: > 3)
Antibodies: 2221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 852
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
17.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase 3
VGNC:2081
461669
Macaque
caspase 3
694473
Mouse
MGI:107739
12367
Rat
RGD:2275
25402
Dog
caspase 3
VGNC:38734
403567
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase 3
Macaque
caspase 3
Mouse
Rat
Dog
caspase 3
Protein Structure (100 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42574-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 100
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (127)
Activation of caspases through apoptosome-mediated cleavage (R-HSA-111459)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of caspases through apoptosome-mediated cleavage
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Name
Explore in Pharos
Explore in Source
Activation of caspases through apoptosome-mediated cleavage
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Gene Ontology Terms (67)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (854)
1 – 10 of 854
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.99956311
p_ni:  0.000436886
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.883099705
p_ni:  0.116900295
Score:  0.205
Data Source:  BioPlex,STRINGDB
LSM14B
Tdark
Novelty:  0.31832554
p_int:  0.817297021
p_ni:  0.182702797
p_wrong:  1.82e-7
Score:  0.241
Data Source:  BioPlex,STRINGDB
SLC35A1
Tbio
Family:  Transporter
Novelty:  0.02071929
p_int:  0.804339891
p_ni:  0.195659774
p_wrong:  3.35e-7
Score:  0.359
Data Source:  BioPlex,STRINGDB
KCNA10
Tclin
Family:  IC
Novelty:  0.05708808
p_int:  0.800333514
p_ni:  0.199666226
p_wrong:  2.6e-7
Score:  0.2
Data Source:  BioPlex,STRINGDB
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.777274371
p_ni:  0.215565616
p_wrong:  0.007160013
Data Source:  BioPlex
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.999
Data Source:  STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
Score:  0.998
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.995
Data Source:  STRINGDB
PARP1
Tclin
Family:  Enzyme
Novelty:  0.00033016
Score:  0.99
Data Source:  STRINGDB
Publication Statistics
PubMed Score  27214.16

PubMed score by year
PubTator Score  15240.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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