You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CASP3
Caspase-3

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308394
  • ENSP00000311032
  • ENSG00000164305
  • ENST00000523916
  • ENSP00000428929

Symbol
  • CPP32
  • CPP32
  • SCA-1
  • CPP32B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
protein domain
0.92
pathway
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27214.16   (req: < 5)
Gene RIFs: 716   (req: <= 3)
Antibodies: 2221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27214.16   (req: >= 5)
Gene RIFs: 716   (req: > 3)
Antibodies: 2221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 852
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (854)
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.99956311
p_ni:  0.000436886
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.883099705
p_ni:  0.116900295
Score:  0.205
Data Source:  BioPlex,STRINGDB
LSM14B
Tdark
Novelty:  0.31832554
p_int:  0.817297021
p_ni:  0.182702797
p_wrong:  1.82e-7
Score:  0.241
Data Source:  BioPlex,STRINGDB
SLC35A1
Tbio
Family:  Transporter
Novelty:  0.02071929
p_int:  0.804339891
p_ni:  0.195659774
p_wrong:  3.35e-7
Score:  0.359
Data Source:  BioPlex,STRINGDB
KCNA10
Tclin
Family:  IC
Novelty:  0.05708808
p_int:  0.800333514
p_ni:  0.199666226
p_wrong:  2.6e-7
Score:  0.2
Data Source:  BioPlex,STRINGDB
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.777274371
p_ni:  0.215565616
p_wrong:  0.007160013
Data Source:  BioPlex
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.999
Data Source:  STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
Score:  0.998
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.995
Data Source:  STRINGDB
PARP1
Tclin
Family:  Enzyme
Novelty:  0.00033016
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 2 of 2
Pathways (127)
Activation of caspases through apoptosome-mediated cleavage (R-HSA-111459)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of caspases through apoptosome-mediated cleavage
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Name
Explore in Pharos
Explore in Source
Activation of caspases through apoptosome-mediated cleavage
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (67)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase 3
VGNC:2081
461669
Macaque
caspase 3
694473
Mouse
MGI:107739
12367
Rat
RGD:2275
25402
Dog
caspase 3
VGNC:38734
403567
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase 3
Macaque
caspase 3
Mouse
Rat
Dog
caspase 3
Publication Statistics
PubMed Score 27214.16
PubMed score by year
PubTator Score 15240.84
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title