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Tchem
CASP3
Caspase-3

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308394
  • ENSP00000311032
  • ENSG00000164305
  • ENST00000523916
  • ENSP00000428929

Symbol
  • CPP32
  • CPP32
  • SCA-1
  • CPP32B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
protein domain
0.92
pathway
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27291.52   (req: < 5)
Gene RIFs: 716   (req: <= 3)
Antibodies: 2221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27291.52   (req: >= 5)
Gene RIFs: 716   (req: > 3)
Antibodies: 2221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 854
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0