Tchem EPS15 Epidermal growth factor receptor substrate 15

Protein Summary

Description

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• P42566
• B2R8J7
• D3DPJ2
• Q5SRH4
• Protein Eps15

Gene Name

• EPS15

Ensembl ID

• ENST00000371733
• ENSP00000360798
• ENSG00000085832

Symbol

• AF1P
• AF1P
• AF-1P
• MLLT5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
drug perturbation	0.96
interacting protein	0.93
hub protein	0.9
cellular component	0.83

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Epidermal Growth Factor Receptor Substrate 15

Protein / Enzyme Modulator / G-protein Modulator / Epidermal Growth Factor Receptor Substrate 15

Protein / Calcium-binding Protein / Epidermal Growth Factor Receptor Substrate 15

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Epidermal Growth Factor Receptor Substrate 15

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.88   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.88   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0