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Tchem
PI4KA
Phosphatidylinositol 4-kinase alpha

Protein Summary
Description
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255882
  • ENSP00000255882
  • ENSG00000241973

Symbol
  • PIK4
  • PIK4CA
  • PIK4CA
  • PMGYCHA
  • pi4K230
  • PI4K-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
molecular function
0.91
drug perturbation
0.87
virus perturbation
0.85
kinase perturbation
0.81


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.97   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.97   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
66.9
monocyte percentage of leukocytes
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
66.9
monocyte percentage of leukocytes
1
10.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol 4-kinase alpha
698020
Mouse
MGI:2448506
224020
Rat
RGD:621213
64161
Dog
phosphatidylinositol 4-kinase alpha
486443
Horse
phosphatidylinositol 4-kinase alpha
VGNC:50961
100057017
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol 4-kinase alpha
Mouse
Rat
Dog
phosphatidylinositol 4-kinase alpha
Horse
phosphatidylinositol 4-kinase alpha
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42356-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the ER membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the ER membrane
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (217)
1 – 10 of 217
PI4KAP1
Tdark
Family: Enzyme
p_int: 1
Data Source: BioPlex
PLBD1
Tdark
Family: Enzyme
Novelty: 0.27639575
p_int: 0.999948187
p_ni: 0.000051812
Data Source: BioPlex
SERPINB7
Tbio
Novelty: 0.01685387
p_int: 0.999828869
p_ni: 0.00017113
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.999724056
p_ni: 0.000275944
Data Source: BioPlex
KLK5
Tchem
Family: Enzyme
Novelty: 0.00835407
p_int: 0.999335705
p_ni: 0.000664295
Data Source: BioPlex
KLK7
Tchem
Family: Enzyme
Novelty: 0.00757766
p_int: 0.9992729
p_ni: 0.000674867
p_wrong: 0.000052234
Data Source: BioPlex
POF1B
Tbio
Novelty: 0.1232792
p_int: 0.999232344
p_ni: 0.000767656
Data Source: BioPlex
A2ML1
Tbio
Novelty: 0.05923067
p_int: 0.998692428
p_ni: 0.001307512
p_wrong: 6e-8
Data Source: BioPlex
CRYAB
Tbio
Novelty: 0.00464213
p_int: 0.997186168
p_ni: 0.002813832
Data Source: BioPlex
SDR9C7
Tbio
Family: Enzyme
Novelty: 0.01618496
p_int: 0.996980571
p_ni: 0.003019429
Data Source: BioPlex
Publication Statistics
PubMed Score  58.97

PubMed score by year
PubTator Score  28.31

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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