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Tclin
MTOR
Serine/threonine-protein kinase mTOR

Protein Summary
Description
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361445
  • ENSP00000354558
  • ENSG00000198793

Symbol
  • FRAP
  • FRAP1
  • FRAP2
  • RAFT1
  • RAPT1
  • SKS
  • FRAP
  • FRAP1
  • FRAP2
  • RAFT1
  • RAPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
molecular function
1
protein domain
1


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9116.26   (req: < 5)
Gene RIFs: 1631   (req: <= 3)
Antibodies: 1535   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9116.26   (req: >= 5)
Gene RIFs: 1631   (req: > 3)
Antibodies: 1535   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 114
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1826
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (1826)
1 – 10 of 1826
CHEMBL1241674
chemical structure image
CHEMBL1081312
chemical structure image
CHEMBL1765602
chemical structure image
CHEMBL1922094
chemical structure image
CHEMBL1615189
chemical structure image
CHEMBL573339,CHEMBL538346
chemical structure image
CHEMBL428496
chemical structure image
CHEMBL1738719
chemical structure image
CHEMBL1914743
chemical structure image
CHEMBL269732
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
5
3
5
99.3
sex hormone-binding globulin measurement
4
1
4
94.2
heel bone mineral density
2
1
2
86.5
2
2
2
80.2
appendicular lean mass
1
1
1
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
5
99.3
sex hormone-binding globulin measurement
4
94.2
heel bone mineral density
2
86.5
2
80.2
appendicular lean mass
1
74.1
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mechanistic target of rapamycin kinase
VGNC:8416
457945
Macaque
mechanistic target of rapamycin kinase
106992736
Mouse
MGI:1928394
56717
Rat
RGD:68371
56718
Dog
mechanistic target of rapamycin kinase
VGNC:43490
478232
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mechanistic target of rapamycin kinase
Macaque
mechanistic target of rapamycin kinase
Mouse
Rat
Dog
mechanistic target of rapamycin kinase
Protein Data Bank (28)
1 – 5 of 28
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (272)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Autophagy
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Cellular response to heat stress
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Autophagy
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Cellular response to heat stress
Gene Ontology Terms (132)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (701)
1 – 10 of 701
MLST8
Tbio
Novelty: 0.00423122
p_int: 0.999999343
p_ni: 6.57e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.999875524
p_ni: 0.000124476
Data Source: BioPlex
RP2
Tbio
Novelty: 0.12345247
p_int: 0.999059578
p_ni: 0.000940422
Data Source: BioPlex
OPALIN
Tdark
Novelty: 0.08221612
p_int: 0.998011496
p_ni: 0.001988503
p_wrong: 1e-9
Data Source: BioPlex
SCN2B
Tbio
Family: IC
Novelty: 0.03773629
p_int: 0.997425231
p_ni: 0.002574769
Data Source: BioPlex
BSG
Tbio
Novelty: 0.0010285
p_int: 0.996498234
p_ni: 0.003501766
Score: 0.276
Data Source: BioPlex,STRINGDB
LEFTY1
Tbio
Novelty: 0.01608284
p_int: 0.995019087
p_ni: 0.004980913
Score: 0.208
Data Source: BioPlex,STRINGDB
EFNA5
Tbio
Novelty: 0.00134985
p_int: 0.994497013
p_ni: 0.005502985
p_wrong: 3e-9
Score: 0.427
Data Source: BioPlex,STRINGDB
CD274
Tclin
Novelty: 0.00013449
p_int: 0.994104629
p_ni: 0.005895371
Score: 0.532
Data Source: BioPlex,STRINGDB
VSIG2
Tdark
Novelty: 0.32398032
p_int: 0.993179235
p_ni: 0.006820765
Data Source: BioPlex
Publication Statistics
PubMed Score  9116.26

PubMed score by year
PubTator Score  10889.85

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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