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Tclin
MTOR
Serine/threonine-protein kinase mTOR

Protein Summary
Description
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361445
  • ENSP00000354558
  • ENSG00000198793

Symbol
  • FRAP
  • FRAP1
  • FRAP2
  • RAFT1
  • RAPT1
  • SKS
  • FRAP
  • FRAP1
  • FRAP2
  • RAFT1
  • RAPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
molecular function
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10851.17   (req: < 5)
Gene RIFs: 1631   (req: <= 3)
Antibodies: 1535   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10851.17   (req: >= 5)
Gene RIFs: 1631   (req: > 3)
Antibodies: 1535   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 114
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1975
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4