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Tchem
PIK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Protein Summary
Description
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289153
  • ENSP00000289153
  • ENSG00000051382
  • ENST00000477593
  • ENSP00000418143

Symbol
  • PIK3C1
  • PI3K
  • PIK3C1
  • P110BETA
  • PI3KBETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
protein domain
1
biological process
0.98
molecular function
0.97
chemical bioactivity profile
0.94


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.09   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 494   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.09   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 494   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 477
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (477)
1 – 10 of 477
CHEMBL3622533
chemical structure image
CHEMBL1081312
chemical structure image
CHEMBL1922094
chemical structure image
CHEMBL1615189
chemical structure image
CHEMBL393525
chemical structure image
CHEMBL573339,CHEMBL538346
chemical structure image
CHEMBL428496
chemical structure image
CHEMBL1738719
chemical structure image
CHEMBL230011
chemical structure image
CHEMBL1914743
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
71.4
platelet count
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
71.4
platelet count
1
0.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
VGNC:2512
471079
Macaque
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
716098
Mouse
MGI:1922019
74769
Rat
RGD:620917
85243
Dog
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
VGNC:44556
477085
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Macaque
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Mouse
Rat
Dog
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P42338-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (261)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 60
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Cell surface interactions at the vascular wall
Reactome
Cell-Cell communication
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Cell surface interactions at the vascular wall
Cell-Cell communication
Constitutive Signaling by Aberrant PI3K in Cancer
Gene Ontology Terms (49)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (353)
1 – 10 of 353
PIK3R3
Tbio
Family: Enzyme
Novelty: 0.0136069
p_int: 0.999974586
p_ni: 0.000025414
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
PCBP1
Tbio
Novelty: 0.00906713
p_int: 0.999880924
p_ni: 0.000119076
Score: 0.201
Data Source: BioPlex,STRINGDB
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.993493548
p_ni: 0.006506452
Data Source: BioPlex
FLRT1
Tdark
Novelty: 0.23047852
p_int: 0.977566739
p_ni: 0.022433224
p_wrong: 3.7e-8
Score: 0.547
Data Source: BioPlex,STRINGDB
BTN3A1
Tbio
Novelty: 0.02572232
p_int: 0.972981646
p_ni: 0.027016158
p_wrong: 0.000002196
Data Source: BioPlex
NLGN3
Tbio
Family: Enzyme
Novelty: 0.00819625
p_int: 0.928914361
p_ni: 0.071078712
p_wrong: 0.000006927
Score: 0.206
Data Source: BioPlex,STRINGDB
EFNB2
Tbio
Novelty: 0.00255095
p_int: 0.914933321
p_ni: 0.085066679
Score: 0.243
Data Source: BioPlex,STRINGDB
CAV1
Tbio
Novelty: 0.00035244
p_int: 0.91134199
p_ni: 0.088546317
p_wrong: 0.000111693
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.869402252
p_ni: 0.130597714
p_wrong: 3.5e-8
Data Source: BioPlex
ZDHHC1
Tdark
Family: Enzyme
Novelty: 0.37323519
p_int: 0.860006104
p_ni: 0.139993896
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  252.09

PubMed score by year
PubTator Score  124.42

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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