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Tbio
ARHGAP25
Rho GTPase-activating protein 25

Protein Summary
Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409030
  • ENSP00000386863
  • ENSG00000163219
  • ENST00000409202
  • ENSP00000386911
  • ENST00000409220
  • ENSP00000386241
  • ENST00000467265
  • ENSP00000420583
  • ENST00000497079
  • ENSP00000417139

Symbol
  • KIAA0053
  • KAIA0053
  • HEL-S-308
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
protein domain
0.58
tissue
0.57
cell line
0.55
transcription factor
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
1
2
80.2
monocyte count
1
1
1
78
alkaline phosphatase measurement
2
2
1
5.8
75.4
platelet count
2
1
2
65.9
lymphocyte percentage of leukocytes
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
80.2
monocyte count
1
78
alkaline phosphatase measurement
1
5.8
75.4
platelet count
2
65.9
lymphocyte percentage of leukocytes
1
64.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 25
VGNC:172
459295
Macaque
Rho GTPase activating protein 25
699828
Mouse
MGI:2443687
232201
Rat
RGD:1562105
500246
Dog
Rho GTPase activating protein 25 [Source:HGNC Symbol;Acc:HGNC:28951]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 25
Macaque
Rho GTPase activating protein 25
Mouse
Rat
Dog
Rho GTPase activating protein 25 [Source:HGNC Symbol;Acc:HGNC:28951]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42331-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (63)
1 – 10 of 63
DMWD
Tbio
Novelty:  0.04096001
p_int:  0.993464634
p_ni:  0.006535364
p_wrong:  1e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
AP5B1
Tdark
Novelty:  0.06116142
p_int:  0.992849182
p_ni:  0.004232178
p_wrong:  0.00291864
Score:  0.188
Data Source:  BioPlex,STRINGDB
PER1
Tbio
Novelty:  0.01290576
p_int:  0.966447741
p_ni:  0.033552259
Data Source:  BioPlex
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
p_int:  0.960153516
p_ni:  0.039842
p_wrong:  0.000004483
Score:  0.177
Data Source:  BioPlex,STRINGDB
DSTYK
Tchem
Family:  Kinase
Novelty:  0.12049855
p_int:  0.909416255
p_ni:  0.090583745
Score:  0.159
Data Source:  BioPlex,STRINGDB
SEC23IP
Tbio
Novelty:  0.0925721
p_int:  0.897017923
p_ni:  0.102982077
Score:  0.189
Data Source:  BioPlex,STRINGDB
MSTO1
Tbio
Novelty:  0.05914188
p_int:  0.853032501
p_ni:  0.146966335
p_wrong:  0.000001163
Score:  0.169
Data Source:  BioPlex,STRINGDB
RECQL4
Tbio
Family:  Enzyme
Novelty:  0.00576141
p_int:  0.851514791
p_ni:  0.14848414
p_wrong:  0.000001068
Score:  0.169
Data Source:  BioPlex,STRINGDB
TBL3
Tdark
Novelty:  0.05195885
p_int:  0.831449524
p_ni:  0.168549524
p_wrong:  9.52e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
WRAP53
Tbio
Family:  Enzyme
Novelty:  0.0204638
p_int:  0.789388113
p_ni:  0.210611887
Score:  0.189
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.60

PubMed score by year
PubTator Score  3.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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