Tchem AKR1C3 Aldo-keto reductase family 1 member C3

Protein Summary

Description

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• P42330
• A8K2V0
• B4DL37
• Q5T2L1
• Q96DJ1
• Q96KI8
• Q99530
• Q9UCX1
• Q9UII3
• Q9UKL9

Gene Name

• AKR1C3

Ensembl ID

• ENST00000380554
• ENSP00000369927
• ENSG00000196139

Symbol

• DDH1
• HSD17B5
• KIAA0119
• PGFS
• DD3
• DDX
• PGFS
• HAKRB
• HAKRe
• HA1753
• HSD17B5
• hluPGFS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
gene perturbation	1
molecular function	0.98
chemical	0.97
small molecule perturbation	0.86

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C3

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.61   (req: < 5)

Gene RIFs: 128   (req: <= 3)

Antibodies: 365   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.61   (req: >= 5)

Gene RIFs: 128   (req: > 3)

Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 394

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9