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Tchem
AKR1C3
Aldo-keto reductase family 1 member C3

Protein Summary
Description
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380554
  • ENSP00000369927
  • ENSG00000196139

Symbol
  • DDH1
  • HSD17B5
  • KIAA0119
  • PGFS
  • DD3
  • DDX
  • PGFS
  • HAKRB
  • HAKRe
  • HA1753
  • HSD17B5
  • hluPGFS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
1
molecular function
0.98
chemical
0.97
small molecule perturbation
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.73   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.73   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 281
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
69.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
69.2
Protein Structure (45 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42330-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 45
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Bile acid and bile salt metabolism
Reactome
Fatty acid metabolism
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Bile acid and bile salt metabolism
Fatty acid metabolism
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (63)
Items per page:
10
1 – 10 of 24
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (101)
1 – 10 of 101
AKR1C1
Tchem
Family: Enzyme
Novelty: 0.0043847
p_int: 1
Score: 0.995
Data Source: BioPlex,STRINGDB
AKR1C4
Tchem
Family: Enzyme
Novelty: 0.00925635
p_int: 1
Score: 0.936
Data Source: BioPlex,STRINGDB
AKR1C2
Tchem
Family: Enzyme
Novelty: 0.00134228
p_int: 0.999999608
p_ni: 3.91e-7
Score: 0.985
Data Source: BioPlex,STRINGDB
AKR1D1
Tbio
Family: Enzyme
Novelty: 0.01264297
p_int: 0.999895163
p_ni: 0.000067742
p_wrong: 0.000037094
Score: 0.985
Data Source: BioPlex,STRINGDB
SRD5A1
Tclin
Family: Enzyme
Novelty: 0.00987219
Score: 0.972
Data Source: STRINGDB
SRD5A2
Tclin
Family: Enzyme
Novelty: 0.00281044
Score: 0.967
Data Source: STRINGDB
HSD3B1
Tchem
Family: Enzyme
Novelty: 0.0019271
Score: 0.967
Data Source: STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
Score: 0.967
Data Source: STRINGDB
CBR1
Tchem
Family: Enzyme
Novelty: 0.0062295
Score: 0.966
Data Source: STRINGDB
CYP17A1
Tclin
Family: Enzyme
Novelty: 0.00065091
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  420.73

PubMed score by year
PubTator Score  367.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer