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Tbio
MTREX
Exosome RNA helicase MTR4

Protein Summary
Description
Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230640
  • ENSP00000230640
  • ENSG00000039123

Symbol
  • DOB1
  • KIAA0052
  • MTR4
  • SKIV2L2
  • Dob1
  • Mtr4
  • SKIV2L2
  • fSAP118
  • KIAA0052
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.7   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.7   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Mtr4 exosome RNA helicase
VGNC:14452
461870
Macaque
Mtr4 exosome RNA helicase
706419
Mouse
MGI:1919448
72198
Dog
Mtr4 exosome RNA helicase
VGNC:46201
607950
Horse
Mtr4 exosome RNA helicase
VGNC:23003
100051945
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Mtr4 exosome RNA helicase
Macaque
Mtr4 exosome RNA helicase
Mouse
Dog
Mtr4 exosome RNA helicase
Horse
Mtr4 exosome RNA helicase
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42285-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (591)
1 – 10 of 591
C1D
Tbio
Novelty: 0.00997109
p_int: 0.98349787
p_ni: 0.01650213
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RBM7
Tbio
Novelty: 0.07482689
p_int: 0.956450233
p_ni: 0.043549767
Score: 0.972
Data Source: BioPlex,STRINGDB
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.955200163
p_ni: 0.044799837
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
EXOSC3
Tbio
Novelty: 0.03072164
p_int: 0.921893952
p_ni: 0.078106048
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC7
Tbio
Family: Enzyme
Novelty: 0.07422851
p_int: 0.816747538
p_ni: 0.183252462
Score: 0.999
Data Source: BioPlex,STRINGDB
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 0.763163505
p_ni: 0.236836495
Score: 0.325
Data Source: BioPlex,STRINGDB
EXOSC5
Tbio
Family: Enzyme
Novelty: 0.03352493
Score: 0.999
Data Source: STRINGDB
DIS3
Tbio
Family: Enzyme
Novelty: 0.00961238
Score: 0.999
Data Source: STRINGDB
EXOSC6
Tbio
Family: Enzyme
Novelty: 0.06031176
Score: 0.999
Data Source: STRINGDB
EXOSC2
Tbio
Novelty: 0.08163283
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  82.70

PubMed score by year
PubTator Score  20.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer