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Tclin
GRIA3
Glutamate receptor 3

Protein Summary
Description
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000541091
  • ENSP00000446440
  • ENSG00000125675
  • ENST00000620443
  • ENSP00000478489
  • ENST00000622768
  • ENSP00000481554

Symbol
  • GLUR3
  • GLURC
  • GLUR3
  • GLURC
  • GluA3
  • MRX94
  • GLUR-C
  • GLUR-K3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.81
molecular function
0.81
transcription factor perturbation
0.74
protein domain
0.73
ligand (chemical)
0.72


Related Tools
GENEVA
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.4   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.4   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glutamate ionotropic receptor AMPA type subunit 3
698396
Mouse
MGI:95810
53623
Rat
RGD:70958
29628
Dog
glutamate ionotropic receptor AMPA type subunit 3
VGNC:41482
492110
Horse
glutamate ionotropic receptor AMPA type subunit 3
VGNC:18580
100055136
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glutamate ionotropic receptor AMPA type subunit 3
Mouse
Rat
Dog
glutamate ionotropic receptor AMPA type subunit 3
Horse
glutamate ionotropic receptor AMPA type subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P42263-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Activation of AMPA receptors (R-HSA-399710)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AMPA receptors
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Activation of AMPA receptors
Activation of NMDA receptors and postsynaptic events
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Protein-Protein Interactions (157)
1 – 10 of 157
GRIA4
Tclin
Family: IC
Novelty: 0.00284417
p_int: 1
Score: 0.948
Data Source: BioPlex,Reactome,STRINGDB
HECTD4
Tbio
Family: Enzyme
Novelty: 0.10275533
p_int: 0.999999982
p_ni: 4e-9
p_wrong: 1.4e-8
Score: 0.21
Data Source: BioPlex,STRINGDB
GLRB
Tclin
Family: IC
Novelty: 0.01721113
p_int: 0.999113019
p_ni: 0.000886937
p_wrong: 4.5e-8
Score: 0.492
Data Source: BioPlex,STRINGDB
CCPG1
Tbio
Novelty: 0.07685013
p_int: 0.992590689
p_ni: 0.007409311
Data Source: BioPlex
CLTCL1
Tbio
Novelty: 0.05667807
p_int: 0.989431447
p_ni: 0.010568553
Score: 0.194
Data Source: BioPlex,STRINGDB
DNAJB9
Tbio
Novelty: 0.00536296
p_int: 0.987711075
p_ni: 0.012288925
Score: 0.158
Data Source: BioPlex,STRINGDB
GLB1L2
Tdark
Family: Enzyme
Novelty: 1.03866932
p_int: 0.956903554
p_ni: 0.043096446
Data Source: BioPlex
SEMA4F
Tbio
Novelty: 0.00574057
p_int: 0.948245937
p_ni: 0.051754063
Score: 0.177
Data Source: BioPlex,STRINGDB
FAM69A
Tdark
Novelty: 0.35978059
p_int: 0.945062949
p_ni: 0.054937051
Data Source: BioPlex
ALG9
Tbio
Family: Enzyme
Novelty: 0.02975572
p_int: 0.934310629
p_ni: 0.065689368
p_wrong: 3e-9
Score: 0.18
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  153.40

PubMed score by year
PubTator Score  159.18

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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