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Tclin
GRIA2
Glutamate receptor 2

Protein Summary
Description
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Glutamate receptors are the predominant ex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264426
  • ENSP00000264426
  • ENSG00000120251
  • ENST00000296526
  • ENSP00000296526
  • ENST00000393815
  • ENSP00000377403
  • ENST00000507898
  • ENSP00000426845
  • ENST00000645636
  • ENSP00000495569

Symbol
  • GLUR2
  • GLUR2
  • GLURB
  • GluA2
  • HBGR2
  • GluR-K2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.99
molecular function
0.86
biological term
0.76
cellular component
0.76
disease perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 761.18   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 597   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 761.18   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 597   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 159
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor AMPA type subunit 2
VGNC:7422
461570
Macaque
glutamate ionotropic receptor AMPA type subunit 2
574344
Mouse
MGI:95809
14800
Rat
RGD:61862
29627
Dog
glutamate ionotropic receptor AMPA type subunit 2
VGNC:41481
482667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor AMPA type subunit 2
Macaque
glutamate ionotropic receptor AMPA type subunit 2
Mouse
Rat
Dog
glutamate ionotropic receptor AMPA type subunit 2
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42262-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (76)
Activation of AMPA receptors (R-HSA-399710)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AMPA receptors
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Name
Explore in Pharos
Explore in Source
Activation of AMPA receptors
Activation of NMDA receptors and postsynaptic events
Gene expression (Transcription)
Generic Transcription Pathway
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Protein-Protein Interactions (352)
1 – 10 of 352
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999999352
p_ni: 3.77e-7
p_wrong: 2.71e-7
Score: 0.154
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999994823
p_ni: 0.000005175
p_wrong: 2e-9
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.999432273
p_ni: 0.000004765
p_wrong: 0.000562961
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.994860852
p_ni: 0.000058869
p_wrong: 0.005080279
Data Source: BioPlex
PICK1
Tbio
Novelty: 0.0058265
Score: 0.995
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.991
Data Source: STRINGDB
CACNG2
Tbio
Family: IC
Novelty: 0.00808502
Score: 0.987
Data Source: STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00284417
Score: 0.986
Data Source: Reactome,STRINGDB
GRIP1
Tbio
Novelty: 0.00343871
Score: 0.983
Data Source: Reactome,STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score  761.18

PubMed score by year
PubTator Score  746.02

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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