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Tclin
GRIA1
Glutamate receptor 1

Protein Summary
Description
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285900
  • ENSP00000285900
  • ENSG00000155511
  • ENST00000340592
  • ENSP00000339343
  • ENST00000448073
  • ENSP00000415569
  • ENST00000518142
  • ENSP00000427920
  • ENST00000518783
  • ENSP00000428994
  • ENST00000521843
  • ENSP00000427864

Symbol
  • GLUH1
  • GLUR1
  • GLUH1
  • GLUR1
  • GLURA
  • GluA1
  • HBGR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
hub protein
0.88
biological term
0.81
kinase
0.8
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2316.81   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 932   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2316.81   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 932   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 73
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6