Protein Classes
Protein Summary
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate re ...more
- ENST00000285900
- ENSP00000285900
- ENSG00000155511
- ENST00000340592
- ENSP00000339343
- ENST00000448073
- ENSP00000415569
- ENST00000518142
- ENSP00000427920
- ENST00000518783
- ENSP00000428994
- ENST00000521843
- ENSP00000427864
- GLUH1
- GLUR1
- GLUH1
- GLUR1
- GLURA
- GluA1
- HBGR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.9 | ||
hub protein | 0.88 | ||
biological term | 0.81 | ||
kinase | 0.8 | ||
trait | 0.75 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1513.92 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 932 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1513.92 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 932 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 68
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Approved Drugs (6)
1 – 6 of 6
Active Ligands (68)
1 – 10 of 68
Pathways (103)
Reactome (22)
KEGG (11)
PathwayCommons (2)
WikiPathways (68)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 22
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of AMPA receptors | ||||
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of AMPA receptors | ||||
Activation of NMDA receptors and postsynaptic events | ||||
Asparagine N-linked glycosylation | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
Gene Ontology Terms (36)
Functions (6)
Components (23)
Processes (7)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (366)
1 – 10 of 366
DLG1
Novelty: 0.00644048
Score: 0.997
Data Source: STRINGDB
DLG4
Novelty: 0.00079421
Score: 0.993
Data Source: STRINGDB
CACNG2
Family: IC
Novelty: 0.01171137
Score: 0.992
Data Source: STRINGDB
PICK1
Novelty: 0.00686801
Score: 0.981
Data Source: Reactome,STRINGDB
PRKCA
Family: Kinase
Novelty: 0.00099987
Score: 0.981
Data Source: STRINGDB
CNIH2
Novelty: 0.11088352
Score: 0.981
Data Source: Reactome,STRINGDB
EPB41L1
Novelty: 0.01521218
Score: 0.978
Data Source: STRINGDB
GRIP1
Novelty: 0.00647926
Score: 0.976
Data Source: Reactome,STRINGDB
CAMK2A
Family: Kinase
Novelty: 0.01196206
Score: 0.97
Data Source: Reactome,STRINGDB
GRIA2
Family: IC
Novelty: 0.00187801
Score: 0.967
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 1513.92
PubMed score by year
PubTator Score 599.08
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEM
1-70
TYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQDALISIIDHY
70-140
KWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLN
140-210
AILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTR
210-280
VDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLT
280-350
GNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
350-420
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAV
420-490
APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF
490-560
SPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSY
560-630
TANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTT
630-700
EEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQ
700-770
GLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
770-840
GFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMPLGATGL
840-906
MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMPLGATGL
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