Protein Summary
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate re ...more
- ENST00000285900
- ENSP00000285900
- ENSG00000155511
- ENST00000340592
- ENSP00000339343
- ENST00000448073
- ENSP00000415569
- ENST00000518142
- ENSP00000427920
- ENST00000518783
- ENSP00000428994
- ENST00000521843
- ENSP00000427864
- GLUH1
- GLUR1
- GLUH1
- GLUR1
- GLURA
- GluA1
- HBGR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.9 | ||
hub protein | 0.88 | ||
biological term | 0.81 | ||
kinase | 0.8 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2117.92 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 932 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2117.92 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 932 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 73
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (73)
Protein-Protein Interactions (366)
Nearest Tclin Targets
Pathways (103)
Reactome (22)
KEGG (11)
PathwayCommons (2)
WikiPathways (68)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of AMPA receptors | ||||
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of AMPA receptors | ||||
Activation of NMDA receptors and postsynaptic events | ||||
Asparagine N-linked glycosylation | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
Viral Interactions (0)
Gene Ontology Terms (36)
Functions (6)
Components (23)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 2 | 2 | 54.2 | |||||
grip strength measurement | 1 | 1 | 1 | 47.7 | |||||
wellbeing measurement | 3 | 1 | 3 | 44.2 | |||||
1 | 1 | 0 | 1.5 | 40.7 | |||||
insomnia measurement | 1 | 2 | 0 | 1 | 38 | ||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 2 | 54.2 | |||||
grip strength measurement | 1 | 47.7 | |||||
wellbeing measurement | 3 | 44.2 | |||||
0 | 1.5 | 40.7 | |||||
insomnia measurement | 0 | 1 | 38 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutamate ionotropic receptor AMPA type subunit 1 | VGNC:8622 | 471714 | |||||
Macaque | glutamate ionotropic receptor AMPA type subunit 1 | 714117 | ||||||
Mouse | MGI:95808 | 14799 | ||||||
Rat | RGD:621531 | 50592 | ||||||
Dog | glutamate ionotropic receptor AMPA type subunit 1 | VGNC:41480 | 489168 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutamate ionotropic receptor AMPA type subunit 1 | |||||
Macaque | glutamate ionotropic receptor AMPA type subunit 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutamate ionotropic receptor AMPA type subunit 1 | |||||
Publication Statistics
PubMed Score 2117.92
PubMed score by year
PubTator Score 599.08
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (109)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
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