Tclin GRIA1 Glutamate receptor 1

Protein Summary

Description

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P42261
• B7Z2S0
• B7Z2W8
• B7Z3F6
• B7Z9G9
• D3DQI4
• E7ESV8
• Q2NKM6
• GluR-1

Gene Name

• GRIA1

Ensembl ID

• ENST00000285900
• ENSP00000285900
• ENSG00000155511
• ENST00000340592
• ENSP00000339343
• ENST00000448073
• ENSP00000415569
• ENST00000518142
• ENSP00000427920
• ENST00000518783
• ENSP00000428994
• ENST00000521843
• ENSP00000427864

Symbol

• GLUH1
• GLUR1
• GLUH1
• GLUR1
• GLURA
• GluA1
• HBGR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
hub protein	0.88
biological term	0.81
kinase	0.8
trait	0.75

Protein Classes

DTO Classes

Protein / Ion Channel / Glutamate-gated Ion Channel (Gic) Family Of Neurotransmitter Receptors / Gria1 Subfamily / Glutamate Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2316.81   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 932   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2316.81   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 932   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 73

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6