Tchem STAT6 Signal transducer and activator of transcription 6

Protein Summary

Description

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• P42226
• A8K316
• B7ZA27
• F5GXI9
• Q5FBW5
• Q71UP4

Gene Name

• STAT6

Ensembl ID

• ENST00000300134
• ENSP00000300134
• ENSG00000166888
• ENST00000454075
• ENSP00000401486
• ENST00000537215
• ENSP00000444530
• ENST00000538913
• ENSP00000445409
• ENST00000543873
• ENSP00000438451
• ENST00000556155
• ENSP00000451742

Symbol

• STAT6B
• STAT6C
• D12S1644
• IL-4-STAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological process	0.97
transcription factor perturbation	0.94
biological term	0.91
transcription factor binding site profile	0.9

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Signal Transducer And Activator Of Transcription 6

Protein / Nucleic Acid Binding / Signal Transducer And Activator Of Transcription 6

DTO Classes

Protein / Nucleic Acid Binding / Signal Transducer And Activator Of Transcription 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1267.23   (req: < 5)

Gene RIFs: 290   (req: <= 3)

Antibodies: 1334   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1267.23   (req: >= 5)

Gene RIFs: 290   (req: > 3)

Antibodies: 1334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 76

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0