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Tchem
STAT6
Signal transducer and activator of transcription 6

Protein Summary
Description
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300134
  • ENSP00000300134
  • ENSG00000166888
  • ENST00000454075
  • ENSP00000401486
  • ENST00000537215
  • ENSP00000444530
  • ENST00000538913
  • ENSP00000445409
  • ENST00000543873
  • ENSP00000438451
  • ENST00000556155
  • ENSP00000451742

Symbol
  • STAT6B
  • STAT6C
  • D12S1644
  • IL-4-STAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.97
transcription factor perturbation
0.94
biological term
0.91
transcription factor binding site profile
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1065.73   (req: < 5)
Gene RIFs: 236   (req: <= 3)
Antibodies: 1334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1065.73   (req: >= 5)
Gene RIFs: 236   (req: > 3)
Antibodies: 1334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 77
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
7
0
1.1
97.7
Eczema
2
1
0
1.1
94.3
2
1
0
1.1
94.3
5
2
2
1.1
86.6
adult onset asthma
2
2
0
1.1
82.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97.7
Eczema
0
1.1
94.3
0
1.1
94.3
2
1.1
86.6
adult onset asthma
0
1.1
82.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal transducer and activator of transcription 6
VGNC:8567
100609243
Macaque
signal transducer and activator of transcription 6
714159
Mouse
MGI:103034
20852
Rat
RGD:1309063
362896
Dog
signal transducer and activator of transcription 6
VGNC:46892
100142679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal transducer and activator of transcription 6
Macaque
signal transducer and activator of transcription 6
Mouse
Rat
Dog
signal transducer and activator of transcription 6
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42226-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (245)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Downstream signal transduction
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
Downstream signal transduction
Immune System
Innate Immune System
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (298)
1 – 10 of 298
IL4
Tbio
Novelty: 0.00005852
Score: 0.997
Data Source: Reactome,STRINGDB
IL4R
Tclin
Novelty: 0.00359183
Score: 0.993
Data Source: Reactome,STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00071141
Score: 0.99
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.99
Data Source: Reactome,STRINGDB
IL13
Tbio
Novelty: 0.00021435
Score: 0.99
Data Source: Reactome,STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00164278
Score: 0.989
Data Source: Reactome,STRINGDB
IRF4
Tbio
Family: TF
Novelty: 0.00192973
Score: 0.987
Data Source: STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.982
Data Source: Reactome,STRINGDB
IL17A
Tclin
Novelty: 0.00011583
Score: 0.982
Data Source: STRINGDB
PARP14
Tbio
Family: Enzyme
Novelty: 0.01791617
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  1065.73

PubMed score by year
PubTator Score  598.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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