Tchem STAT1 Signal transducer and activator of transcription 1-alpha/beta

Protein Summary

Description

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P42224
• A8K989
• B2RCA0
• D2KFR8
• D3DPI7
• Q53S88
• Q53XW4
• Q68D00
• Q9UDL5

Gene Name

• STAT1

Ensembl ID

• ENST00000361099
• ENSP00000354394
• ENSG00000115415
• ENST00000392322
• ENSP00000376136
• ENST00000409465
• ENSP00000386244

Symbol

• CANDF7
• IMD31A
• IMD31B
• IMD31C
• ISGF-3
• STAT91

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
hub protein	1
interacting protein	1
kinase	1

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Signal Transducer And Activator Of Transcription 1-alpha/beta

Protein / Nucleic Acid Binding / Signal Transducer And Activator Of Transcription 1-alpha/beta

DTO Classes

Protein / Nucleic Acid Binding / Signal Transducer And Activator Of Transcription 1-alpha/beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3465.54   (req: < 5)

Gene RIFs: 796   (req: <= 3)

Antibodies: 2120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3465.54   (req: >= 5)

Gene RIFs: 796   (req: > 3)

Antibodies: 2120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0