Tbio P42167 Lamina-associated polypeptide 2, isoforms beta/gamma

Protein Summary

Description

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95. Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P42167
• A2T926
• Q14861

Gene Name

• TMPO

Ensembl ID

• ENST00000261210
• ENSP00000261210
• ENSG00000120802
• ENST00000393053
• ENSP00000376773
• ENST00000556029
• ENSP00000450627

Symbol

• LAP2
• TP
• LAP2
• CMD1T
• LEMD4
• PRO0868

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein complex	1
transcription factor perturbation	1
ligand (protein) perturbation	0.99
transcription factor binding site profile	0.96

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.92   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 350   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.92   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0