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Tbio
TMPO
Lamina-associated polypeptide 2, isoform alpha

Protein Summary
Description
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1. TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266732
  • ENSP00000266732
  • ENSG00000120802

Symbol
  • LAP2
  • TP
  • LAP2
  • CMD1T
  • LEMD4
  • PRO0868
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.7   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.7   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Depolymerisation of the Nuclear Lamina
Reactome
Initiation of Nuclear Envelope Reformation
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Depolymerisation of the Nuclear Lamina
Initiation of Nuclear Envelope Reformation
M Phase
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (86)
1 – 10 of 86
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.982
Data Source: STRINGDB
LMNB1
Tbio
Novelty: 0.00127348
Score: 0.784
Data Source: STRINGDB
LMNB2
Tbio
Novelty: 0.0019221
Score: 0.722
Data Source: STRINGDB
LEMD3
Tbio
Novelty: 0.00579701
Score: 0.711
Data Source: STRINGDB
ERBIN
Tbio
Novelty: 0.01419561
Score: 0.71
Data Source: STRINGDB
MAD2L1
Tbio
Novelty: 0.01623659
Score: 0.703
Data Source: STRINGDB
LMNA
Tbio
Novelty: 0.00046972
Score: 0.697
Data Source: STRINGDB
NEDD1
Tbio
Novelty: 0.03077131
Score: 0.684
Data Source: STRINGDB
ZNF451
Tbio
Family: TF
Novelty: 0.13852406
Score: 0.671
Data Source: STRINGDB
PNPLA8
Tbio
Family: Enzyme
Novelty: 0.02380129
Score: 0.667
Data Source: STRINGDB
Publication Statistics
PubMed Score  299.70

PubMed score by year
PubTator Score  101.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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