Tbio ASIP Agouti-signaling protein

Protein Summary

Description

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P42127
• Q3SXL2
• ASP

Gene Name

• ASIP

Ensembl ID

• ENST00000374954
• ENSP00000364092
• ENSG00000101440
• ENST00000568305
• ENSP00000454804

Symbol

• AGTI
• AGTIL
• ASP
• ASP
• AGSW
• AGTI
• AGTIL
• SHEP9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.63
biological process	0.59
tissue sample	0.57
phenotype	0.54
tissue	0.49

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Agouti-signaling Protein

DTO Classes

Protein / Signaling / Agouti-signaling Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.59   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.59   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0