Tclin CD86 T-lymphocyte activation antigen CD86

Protein Summary

Description

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

Uniprot Accession IDs

• P42081
• A0N0P0
• B7Z2F3
• B7Z702
• E7ETN5
• E9PC27
• Q13655
• Q6FHB1
• Q6GTS4
• Q7M4L5

Gene Name

• CD86

Ensembl ID

• ENST00000264468
• ENSP00000264468
• ENSG00000114013
• ENST00000330540
• ENSP00000332049
• ENST00000393627
• ENSP00000377248
• ENST00000469710
• ENSP00000418988
• ENST00000493101
• ENSP00000420230

Symbol

• CD28LG2
• B70
• B7-2
• B7.2
• LAB72
• CD28LG2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
biological term	0.91
disease	0.8
PubMedID	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3518.9   (req: < 5)

Gene RIFs: 166   (req: <= 3)

Antibodies: 1775   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3518.9   (req: >= 5)

Gene RIFs: 166   (req: > 3)

Antibodies: 1775   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2